Table 3 Correlation of clinicopathological features with the LEP and LEPR expression
From: Leptin and leptin receptor expression as biomarkers for breast cancer: a retrospective study
Clinicopathological features | LEPR expression level (n = 132) | LEP expression level (n = 132) | ||||
|---|---|---|---|---|---|---|
High (%) | Low (%) | P-value | High (%) | Low (%) | P-value | |
Menstrual status | Â | Â | 0.820 | Â | Â | 0.161 |
 Premenopausal | 71 (72.4) | 27 (27.6) |  | 72 (73.5) | 26 (26.5) |  |
 Postmenopausal | 24 (70.6) | 10 (29.4) | 29 (85.3) | 5 (14.7) | ||
Tumor size | Â | Â | 0.709 | Â | Â | 0.832 |
  ≤ 2 cm | 35 (66.0) | 18 (34.0) |  | 42 (79.2) | 11 (20.8) |  |
 2 ~ 5 cm | 52 (73.2) | 19 (26.8) | 53 (74.6) | 18 (25.4) | ||
  > 5 cm | 6 (75.0) | 2 (25.0) | 6 (75) | 2 (25) | ||
Tumor grade | Â | Â | 0.874 | Â | Â | 0.397 |
 I | 7 (70.0) | 3 (30.0) |  | 6 (60.0) | 4 (40.0) |  |
 II | 43 (72.9) | 16 (27.1) | 47 (79.7) | 12 (20.3) | ||
 III | 43 (68.3) | 20 (31.7) | 48 (76.2) | 15 (24.2) | ||
TNM stage | Â | Â | 0.849 | Â | Â | 0.428 |
 0 | 1 (50.0) | 1 (50.0) |  | 1 (50.0) | 1 (50.0) |  |
 I | 26 (68.4) | 12 (31.6) | 28 (73.7) | 10 (26.3) | ||
 II | 49 (70.0) | 21 (30.0) | 52 (74.3) | 18 (25.7) | ||
 III | 14 (73.7) | 5 (26.3) | 17 (89.5) | 2 (10.5) | ||
 IV | 3 (100.0) | 0 (0) | 3 (100.0) | 0 (0) | ||
Histological type | Â | Â | 0.831 | Â | Â | 0.508 |
 IDC | 42 (72.4) | 16 (27.6) |  | 45 (77.6) | 13 (22.4) |  |
 DCIS | 39 (70.9) | 16 (29.1) | 42 (76.4) | 13 (23.6) | ||
 ILC | 6 (66.7) | 3 (33.3) | 8 (88.9) | 1 (11.1) | ||
 LIN | 6 (60.0) | 4 (40.0) | 6 (60.0) | 4 (40.0) | ||
Lymph node metastasis | Â | Â | 0.660 | Â | Â | 0.002 |
 Yes | 36 (73.5) | 13 (26.5) |  | 45 (91.8) | 4 (8.2) |  |
 No | 58 (69.9) | 25 (30.1) | 56 (67.5) | 27 (32.5) | ||
Distant metastases | Â | Â | 0.884 | Â | Â | 0.684 |
 Yes | 2 (66.7) | 1 (33.3) |  | 2 (66.7) | 1 (33.3) |  |
 No | 91 (70.5) | 38 (29.5) | 99 (76.7) | 30 (23.3) | ||
Estrogen receptor | Â | Â | 0.394 | Â | Â | 0.564 |
 Positive | 71 (72.4) | 27 (27.6) |  | 73 (74.5) | 25 (25.5) |  |
 Negative | 22 (64.7) | 12 (35.3) | 27 (79.4) | 7 (20.6) | ||
Progesterone receptor |  |  | 0.648 |  |  | 0.298 |
 Positive | 68 (69.4) | 30 (30.6) |  | 72 (73.5) | 26 (26.5) |  |
 Negative | 25 (73.5) | 9 (26.5) | 28 (82.4) | 6 (17.6) | ||
Ki-67 | Â | Â | 0.002 | Â | Â | 0.487 |
 Positive | 75(68.8) | 34(31.2) |  | 70(64.2) | 39(35.8) |  |
 Negative | 8(34.8) | 15(65.2) |  | 13(56.5) | 10(43.5) |  |