| Q1 | Q2 | Q3 | Q4 | Q5 | p trend†| q trend§ |
---|---|---|---|---|---|---|---|
 | Reference |  |  |  |  |  |  |
Total SFA a | Â | Â | Â | Â | Â | Â | Â |
Mean Intake ± SD (g/d) | 13.49 ± 2.79 | 19.88 ± 1.47 | 25.01 ± 1.53 | 31.12 ± 2.11 | 44.59 ± 9.16 |  |  |
Cases/non-cases (n) | 460/59,404 | 389/59,475 | 379/59,484 | 338/59,526 | 320/59,543 | Â | Â |
 h (95% CI) * | 1.00 | 0.89 (0.77;1.03) | 0.91 (0.77;1.06) | 0.87 (0.73;1.05) | 0.94 (0.75;1.18) | 0.45 | 0.86 |
Palmitic acid (16:0) | Â | Â | Â | Â | Â | Â | Â |
Mean Intake ± SD (g/d) | 7.51 ± 1.45 | 10.77 ± 0.74 | 13.30 ± 0.75 | 16.25 ± 0.99 | 22.49 ± 4.15 |  |  |
Cases/non-cases (n) | 442/59,422 | 402/59,462 | 396/59,467 | 335/59,529 | 311/59,552 | Â | Â |
 h (95% CI)* | 1.00 | 0.95 (0.82;1.10) | 0.96 (0.81;1.12) | 0.88 (0.73;1.06) | 0.90 (0.71;1.14) | 0.25 | 0.86 |
Stearic acid (18:0) | Â | Â | Â | Â | Â | Â | Â |
Mean Intake ± SD (g/d) | 3.10 ± 0.66 | 4.61 ± 0.34 | 5.79 ± 0.35 | 7.20 ± 0.48 | 10.24 ± 2.12 |  |  |
Cases/non-cases (n) | 420/59,444 | 395/59,469 | 388/59,475 | 365/59,499 | 318/59,594 | Â | Â |
 h (95% CI)* | 1.00 | 0.96 (0.82;1.11) | 0.91 (0.78; 1.11) | 0.91 (0.76;1.09) | 0.85 (0.68;1.07) | 0.19 | 0.82 |
Total cis -MUFA b | Â | Â | Â | Â | Â | Â | Â |
Mean Intake ± SD (g/d) | 13.79 ± 2.64 | 19.86 ± 1.40 | 24.77 ± 1.48 | 30.82 ± 2.13 | 44.61 ± 9.49 |  |  |
Cases/non-cases (n) | 437/59,427 | 404/59,460 | 403/59,460 | 359/59,505 | 283/59,580 | Â | Â |
 h (95% CI)* | 1.00 | 1.02 (0.88;1.18) | 1.09 (0.93;1.29) | 1.06 (0.87;1.29) | 0.99 (0.77;1.28) | 0.72 | 0.96 |
Oleic acid (18:1n-9) | Â | Â | Â | Â | Â | Â | Â |
Mean Intake ± SD (g/d) | 12.72 ± 2.45 | 18.45 ± 1.33 | 23.14 ± 1.42 | 28.96 ± 2.04 | 42.32 ± 9.26 |  |  |
Cases/non-cases (n) | 448/59,417 | 402/59,461 | 391/59,472 | 365/59,499 | 280/59,583 | Â | Â |
 h (95% CI)* | 1.00 | 0.99 (0.86;1.15) | 1.04 (0.88;1.23) | 1.06 (0.87;1.29) | 0.97 (0.75;1.25) | 0.74 | 0.96 |
Total ruminant trans fatty acids d | Â | Â | Â | Â | Â | Â | Â |
Mean Intake ± SD (mg/d) | 6.00 ± 3.00 | 15.00 ± 3.00 | 29.00 ± 5.00 | 52.00 ± 8.00 | 120.00 ± 57.00 |  |  |
Cases/non-cases (n) | 493/59,372 | 362/59,502 | 386/59,476 | 330/59,534 | 315/59,548 | Â | Â |
 h (95% CI)* | 1.00 | 0.95 (0.81;1.11) | 1.10 (0.93;1.29) | 1.02 (0.85;1.22) | 1.13 (0.93;1.38) | 0.22 | 0.86 |
Total industrial trans fatty acids e | Â | Â | Â | Â | Â | Â | Â |
Mean Intake ± SD (g/d) | 0.30 ± 0.14 | 0.73 ± 0.12 | 1.20 ± 0.15 | 1.93 ± 0.28 | 4.19 ± 1.68 |  |  |
Cases/non-cases (n) | 358/59,506 | 356/59,508 | 369/59,494 | 391/59,473 | 412/59,451 | Â | Â |
 h (95% CI)* | 1.00 | 1.12 (0.95;1.32) | 1.08 (0.91;1.29) | 1.08 (0.90;1.30) | 1.05 (0.86;1.27) | 0.92 | 0.98 |
Elaidic acid (18:1n-9/12) | Â | Â | Â | Â | Â | Â | Â |
Mean Intake ± SD (g/d) | 0.27 ± 0.13 | 0.69 ± 0.12 | 1.13 ± 0.15 | 1.85 ± 0.28 | 4.13 ± 1.68 |  |  |
Cases/non cases (n) | 357/59,507 | 353/59,511 | 364/59,499 | 398/59,466 | 414/59,449 | Â | Â |
 h (95% CI)* | 1.00 | 1.12 (0.95;1.33) | 1.09 (0.91;1.31) | 1.11 (0.92;1.34) | 1.06 (0.87; 1.30) | 0.77 | 0.96 |
Total cis n-6 PUFA f | Â | Â | Â | Â | Â | Â | Â |
Mean Intake ± SD (g/d) | 6.51 ± 1.17 | 9.21 ± 0.63 | 11.43 ± 0.67 | 14.20 ± 0.98 | 20.76 ± 4.83 |  |  |
Cases/non-cases (n) | 468/59,396 | 360/59,504 | 360/59,503 | 389/59,475 | 309/59,554 | Â | Â |
 h (95% CI)* | 1.00 | 0.87 (0.75;1.01) | 0.87 (0.74;1.02) | 1.01 (0.85;1.20) | 0.83 (0.67;1.01) | 0.43 | 0.86 |
Linoleic acid (18:2n-6) | Â | Â | Â | Â | Â | Â | Â |
Mean Intake ± SD (g/d) | 6.48 ± 1.16 | 9.18 ± 0.63 | 11.40 ± 0.67 | 14.15 ± 0.97 | 20.70 ± 4.80 |  |  |
Cases/non-cases (n) | 468/59,396 | 358/59,506 | 364/59,499 | 386/59,478 | 310/59,553 | Â | Â |
 h (95% CI)* | 1.00 | 0.86 (0.75;1.00) | 0.88 (0.75;1.03) | 1.00 (0.85;1.19) | 0.83 (0.68;1.02) | 0.46 | 0.86 |
γ-linolenic acid (18:3n-6) |  |  |  |  |  |  |  |
Mean Intake ± SD (mg/d) | 2.48 ± 0.86 | 4.92 ± 0.66 | 7.38 ± 0.78 | 10.91 ± 0.38 | 21.79 ± 9.58 |  |  |
Cases/non-cases (n) | 388/59,495 | 393/59,454 | 414/59,461 | 378/59,474 | 313/59,548 | Â | Â |
 h (95% CI)* | 1.00 | 0.92 (0.80;1.07) | 0.97 (0.83;1.13) | 0.91 (0.78;1.08) | 0.77 (0.64;0.92) | 0.01 | 0.15 |
Total long-chain n-6 PUFA g | Â | Â | Â | Â | Â | Â | Â |
Mean Intake ± SD (mg/d) | 8.00 ± 3.00 | 17.00 ± 2.00 | 24.00 ± 2.00 | 34.00 ± 4.00 | 61.00 ± 24.00 |  |  |
Cases/non-cases (n) | 356/59,510 | 396/59,471 | 386/59,477 | 390/59,473 | 358/59,501 | Â | Â |
 h (95% CI)* | 1.00 | 0.94 (0.81;1.10) | 0.96 (0.81;1.12) | 0.99 (0.84;1.17) | 0.93 (0.77;1.11) | 0.65 | 0.96 |
Total cis n-3 PUFA h | Â | Â | Â | Â | Â | Â | Â |
Mean Intake ± SD (g/d) | 0.29 ± 0.08 | 0.49 ± 0.05 | 0.67 ± 0.06 | 0.93 ± 0.10 | 1.70 ± 0.61 |  |  |
Cases/non-cases (n) | 350/59,514 | 372/59,492 | 341/59,522 | 395/59,469 | 428/59,435 | Â | Â |
 h (95% CI)* | 1.00 | 1.00 (0.85;1.17) | 0.91 (0.77;1.08) | 0.97 (0.81;1.15) | 0.91 (0.75;1.10) | 0.33 | 0.86 |
α-linolenic acid (18:3n-3) |  |  |  |  |  |  |  |
Mean Intake ± SD (g/d) | 0.15 ± 0.05 | 0.27 ± 0.03 | 0.38 ± 0.04 | 0.56 ± 0.07 | 1.10 ± 0.44 |  |  |
Cases/non-cases (n) | 367/59,497 | 405/59,461 | 379/59,482 | 350/59,515 | 385/59,477 | Â | Â |
 h (95% CI)* | 1.00 | 1.08 (0.93;1.26) | 1.05 (0.89;1.23) | 0.96 (0.81;1.14) | 0.94 (0.78;1.14) | 0.27 | 0.86 |
Total long-chain n-3 PUFA i | Â | Â | Â | Â | Â | Â | Â |
Mean Intake (mg/d) | 40.00 ± 21.00 | 115.00 ± 21.00 | 198.00 ± 27.00 | 338.00 ± 61.00 | 933.00 ± 609.00 |  |  |
Cases/non-cases (n) | 333/59,531 | 320/59,545 | 363/59,499 | 401/59,463 | 469/59,394 | Â | Â |
 h (95% CI)* | 1.00 | 0.91 (0.77;1.07) | 0.95 (0.80;1.12) | 0.95 (0.80;1.13) | 0.95 (0.79;1.15) | 0.84 | 0.96 |
Ratio n-6/n-3 PUFA | Â | Â | Â | Â | Â | Â | Â |
Mean Intake ± SD | 7.76 ± 2.29 | 13.06 ± 1.24 | 17.47 ± 1.34 | 23.16 ± 2.07 | 39.06 ± 28.95 |  |  |
Cases/non-cases (n) | 491/59,373 | 419/59,445 | 334/59,529 | 334/59,530 | 308/59,555 | Â | Â |
 h (95% CI)* | 1.00 | 1.11 (0.96;1.28) | 0.96 (0.81;1.13) | 1.03 (0.86;1.22) | 1.04 (0.86;1.24) | 0.98 | 0.98 |