EPIC-wide study | Â | Â |
---|---|---|
Endometrial cancer cases | Non cases* | |
N = 299,318 | n = 1,886 | n = 297,432 |
Histological subtypes, number, (%**) | Â | Â |
Type I§ | 1690 (89.6) | - |
Type II§ | 90 (4.7) | - |
Follow-up characteristics Mean ± SD** |  |  |
Age at recruitment, years | 54.9 ± 7.5 | 50.2 ± 9.9 |
Age at diagnosis, years | 63.7 ± 8.1 | - |
Follow-up, years | 8.8 ± 4.7 | 14.0 ± 3.8 |
Anthropometry Mean ± SD** |  |  |
Weight, kg | 70.9 ± 13.9 | 65.3 ± 11.6 |
Height, cm | 162.2 ± 6.6 | 162.3 ± 6.7 |
BMI, kg/m2 | 26.9 ± 5.3 | 24.8 ± 4.4 |
Obese (BMI ≥30 kg/m2), %** | 24.2 | 12.1 |
Reproductive and hormone factors | Â | Â |
Number of full-term pregnancies# | 1.9 ± 1.2 | 1.9 ± 1.2 |
Nulliparous, % | 16.4 | 15.6 |
Ever use Oral contraceptives, %** | Â | Â |
Never | 58.6 | 40.2 |
Ever | 41.4 | 59.7 |
Ever use hormone replacement therapy##, %** | Â | Â |
Never | 66.3 | 76.9 |
Ever | 33.7 | 23.1 |
Ever breastfed#, %** | Â | Â |
No | 28.7 | 27.9 |
Yes | 71.3 | 72.1 |
Menopausal Status, %** | Â | Â |
Premenopausal | 20.5 | 38.2 |
Post-menopausal | 59.5 | 43.8 |
Perimenopausal | 19.6 | 17.7 |
Age at menopause## | 50.9 ± 4.1 | 49.3 ± 4.4 |
Socio-economic status and lifestyle | Â | Â |
Total energy intake, Kcal/day | 1949.5 ± 539.8 | 1993.1 ± 546.1 |
Alcohol intake, %** | Â | Â |
None | 18.5 | 16.4 |
< 5 g/day | 32.7 | 31.9 |
5 to ≤ 14.9 g/day | 28.2 | 30.1 |
15.0 to < 29.9 g/day | 12.7 | 13.2 |
≥29.9 g/day | 7.3 | 7.7 |
Education status, % | Â | Â |
None and primary school | 33.8 | 27.8 |
Technical or professional and secondary school | 44.1 | 45.0 |
Higher education | 17.8 | 23.6 |
Physical activity status, %** | Â | Â |
Inactive | 14.2 | 15.2 |
Moderately inactive | 34.5 | 35.9 |
Moderately active | 43.4 | 40.7 |
Active | 7.9 | 8.2 |
Smoking status, %** | Â | Â |
Never | 62.7 | 56.8 |
Former | 21.7 | 22.9 |
Current Other non-communicable diseases number, (%**) | 15.5 | 20.2 |
Diabetes | 68 (4.1) | 6149 (2.2) |
Hyperlipidemia | 205 (15.7) | 30,481 (13.5) |
Hypertension | 452 (29.4) | 48,832 (18.8) |
Myocardial infarction | 20 (1.2) | 1754 (0.6) |
Stroke | 17 (1.1) | 1783 (0.7) |
Dietary intake, (g/day) Median (95%CI)** | Â | Â |
Dairy products | 255.3 (245.7-265.2) | 242.2 (241.4-242.9) |
Fruits, nuts and seeds | 199.6 (192.4-207.1) | 190.6 (190.0-191.2) |
Vegetables | 168.7 (163.7-173.9) | 178.1 (177.7-178.5) |
Cereal and cereal products | 173.1 (169.3-176.9) | 182.5 (182.1-182.8) |
Meat and meat products | 71.3 (68.3–74.5) | 61.3 (61.1–61.6) |
Fish and shellfish | 28.6 (27.2–29.9) | 26.6 (26.5–26.7) |
Egg and egg products | 11.8 (11.3–12.4) | 11.5 (16.7–18.3) |
Fat | 19.4 (18.8–20.1) | 20.0 (19.9–20.1) |
Fatty acid intake ### (g/day or mg/day) Median (95%CI)** | Â | Â |
SFA (g/day) | 23.7 (11.2–45.8) | 24.9 (11.7–48.3) |
Cis MUFA (g/day) | 23.4 (11.3–45.2) | 24.7 (12.1–48.5) |
rTFA (mg/day) | 22.9 (3.1-116.4) | 27.9 (4.3-134.5) |
iTFA (g/day) | 1.2 (0.1–5.3) | 1.2 (0.2–4.9) |
n-6 PUFA (g/day) | 11.0 (5.4–21.4) | 11.4 (5.8–22.5) |
n-6 linoleic acid (g/day) | 10.9 (5.3–21.3) | 11.38 (5.7–22.4) |
n-6 γ-Linolenic acid (mg/day) | 6.9 (1.9–22.5) | 7.3 (1.8–24.3) |
n-6 long-chain PUFA (mg/day) | 23.7 (7.4–66.7) | 24.2 (5.5–66.0) |
n-3 PUFA (mg/day) | 701.5 (254.0-1945.3) | 667.2 (237.5-1913.2) |
n-3 α-linolenic acid (mg/day) | 379.4 (116.7-1263.6) | 382.2 (117.5-1251.9) |
n-3 long-chain PUFA (mg/day) | 229.1 (28.8-1156.8) | 198.1 (21.7-1051.9) |