Association between diverticular disease and colorectal cancer: a bidirectional mendelian randomization study

BMC Cancer

Table 2 MR-PRESSO results of bidirectional Mendelian randomization analysis

exposure	outcome data sources	outcome	N_snp	outlier	P_{_Global test}	P_{_Distortion test}	MR analysis	Beta	LCI	UCI	P
Diverticular disease	FinnGen	Colorectal cancer	34	1	0.009	0.551	Raw	0.409	0.063	0.754	0.026
		Colorectal cancer	34	1	0.009	0.551	Outlier-corrected	0.337	0.020	0.653	0.044
		Colon cancer	34	2	0.003	0.855	Raw	0.412	-0.035	0.860	0.079
		Colon cancer	34	2	0.003	0.855	Outlier-corrected	0.447	0.049	0.844	0.034
		Rectum cancer	34	0	0.901	NA	Raw	0.307	-0.052	0.667	0.102
		Rectum cancer	34	0	0.901	NA	Outlier-corrected	NA	NA	NA	NA
	UK Biobank	Colorectal cancer	39	0	0.009	NA	Raw	0.153	-0.147	0.452	0.324
		Colorectal cancer	39	0	0.009	NA	Outlier-corrected	NA	NA	NA	NA
		Colon cancer	39	0	0.159	NA	Raw	0.158	-0.161	0.476	0.337
		Colon cancer	39	0	0.159	NA	Outlier-corrected	NA	NA	NA	NA
		Rectum cancer	39	1	< 0.001	0.041	Raw	0.109	-0.353	0.570	0.647
		Rectum cancer	39	1	< 0.001	0.041	Outlier-corrected	-0.017	-0.455	0.422	0.941
Colorectal cancer	Meta-analysis of GWAS	Diverticular disease	64	1	< 0.001	0.709	Raw	0.008	0.006	0.011	1.95E-08
Colorectal cancer	Meta-analysis of GWAS	Diverticular disease	64	1	< 0.001	0.709	Outlier-corrected	0.009	0.007	0.011	9.56E-11

N_snp, the number of SNPs used in the analysis. LCI, lower 95% confidence interval. UCI, upper 95% confidence interval. P_{_Global test,} the p value of global test in MR-PRESSO analysis. P_{_Distortion test,} the p value of distortionl test in MR-PRESSO analysis

ISSN: 1471-2407