Association between diverticular disease and colorectal cancer: a bidirectional mendelian randomization study

BMC Cancer

Table 1 Results of bidirectional Mendelian randomization analysis, stratified analysis, and sensitivity analysis

exposure	outcome	outcome data sources	method	N_snp	beta	LCI	UCI	P_− effect	P_{− heterogeneity}	P_{− intercept}
diverticular disease	colon cancer	FinnGen	MR Egger	34	0.913	-0.502	2.328	0.215	0.004	0.538
			Weighted median	34	0.690	0.103	1.278	0.021
			Inverse variance weighted	34	0.489	0.020	0.959	0.041
		UK Biobank	MR Egger	39	0.989	-0.045	2.023	0.069	0.123	0.125
			Weighted median	39	0.326	-0.145	0.798	0.175
			Inverse variance weighted	39	0.206	-0.140	0.551	0.243
	rectum cancer	FinnGen	MR Egger	34	1.066	-0.271	2.402	0.128	0.880	0.259
			Weighted median	34	0.350	-0.291	0.990	0.284
			Inverse variance weighted	34	0.328	-0.119	0.775	0.151
		UK Biobank	MR Egger	39	1.723	0.270	3.176	0.026	< 0.001	0.029
			Weighted median	39	0.415	-0.186	1.015	0.176
			Inverse variance weighted	39	0.134	-0.367	0.636	0.600
	colorectal cancer	FinnGen	MR Egger	34	0.768	-0.317	1.853	0.175	0.008	0.535
			Weighted median	34	0.561	0.109	1.014	0.015
			Inverse variance weighted	34	0.441	0.081	0.801	0.016
		UK Biobank	MR Egger	39	1.309	0.381	2.237	0.009	0.008	0.019
			Weighted median	39	0.120	-0.291	0.532	0.567
			Inverse variance weighted	39	0.208	-0.115	0.532	0.207
colorectal cancer	diverticular disease	Meta-analysis of GWASs	MR Egger	64	0.005	-0.004	0.014	0.291	3.80E-06	0.617
			Weighted median	64	0.008	0.005	0.011	4.98E-07
			Inverse variance weighted	64	0.007	0.004	0.010	4.01E-07

N_snp, the number of SNPs used in the analysis. LCI, lower 95% confidence interval. UCI, upper 95% confidence interval. P_{− heterogeneity,} the p value of Cochrane’s Q test for inverse variance weighted approach. P_{− intercept}, the p value of test for directional pleiotropy by Egger-intercept

ISSN: 1471-2407