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Table 1 General characteristics of patients with resected first primary oral cavity squamous cell carcinoma according to the relapse interval (early, ≤ 330 days versus late, > 330 days) before and after propensity score matching

From: Early relapse is an adverse prognostic factor for survival outcomes in patients with oral cavity squamous cell carcinoma: results from a nationwide registry study

Characteristic (n)

Original cohort (n = 2327)

Propensity score-matched cohort

(n = 1308)

Early relapse

(n = 1630)

Late relapse

(n = 697)

p a

SMD (%)

Early relapse

(n = 654)

Late relapse

(n = 654)

p b

SMD (%)

Tumor subsite

  

< 0.0001

   

0.9819

 

Lip (70)

42 (2.6)

28 (4.0)

 

-8.07

21 (3.2)

24 (3.7)

 

-2.52

Tongue (925)

700 (42.9)

225 (32.3)

 

22.15

232 (35.5)

221 (33.8)

 

3.54

Gum (295)

212 (13.0)

83 (11.9)

 

3.33

81 (12.4)

79 (12.1)

 

0.93

Mouth floor (75)

53 (3.3)

22 (3.2)

 

0.54

23 (3.5)

22 (3.4)

 

0.84

Hard palate (35)

28 (1.7)

7 (1.0)

 

6.16

8 (1.2)

7 (1.1)

 

1.44

Buccal (742)

473 (29.0)

269 (38.6)

 

-20.35

234 (35.8)

245 (37.5)

 

-3.49

Retromolar (117)

77 (4.7)

40 (5.7)

 

-4.56

33 (5.0)

37 (5.7)

 

-2.72

Other sites (68)

45 (2.8)

23 (3.3)

 

-3.15

22 (3.4)

19 (2.7)

 

2.63

Sex

  

< 0.0001

   

0.6682

 

Men (2141)

1474 (90.4)

667 (95.7)

 

-20.84

621 (95)

624 (95.4)

 

-2.14

Women (186)

156 (9.6)

30 (4.3)

 

20.84

33 (5)

30 (4.6)

 

2.14

Age (years)

  

0.0204

   

0.9244

 

< 65 (2015)

1394 (85.5)

621 (89.1)

 

-10.75

581 (88.8)

580 (88.7)

 

0.48

≥ 65 (312)

236 (14.5)

76 (10.9)

 

10.75

73 (11.2)

74 (11.3)

 

-0.48

Alcohol drinking

  

0.2019

   

0.5090

 

No (730)

511 (31.3)

219 (31.4)

 

-0.15

204 (31.2)

206 (31.5)

 

-0.66

Yes (1586)

1114 (68.3)

472 (67.7)

 

1.34

448 (68.5)

443 (67.7)

 

1.64

Missing data (11)

5 (0.4)

6 (0.9)

 

-7.28

2 (0.3)

5 (6.8)

 

-6.29

Betel quid chewing

  

0.2523

   

0.8145

 

No (595)

432 (26.5)

163 (23.4)

 

7.21

156 (23.9)

158 (24.2)

 

-0.72

Yes (1716)

1186 (72.8)

530 (76.0)

 

-7.52

492 (75.2)

492 (75.2)

 

0.00

Missing data (16)

12 (0.7)

4 (0.6)

 

2.01

6 (0.9)

4 (0.6)

 

3.51

Cigarette smoking

  

0.0115

   

0.6065

 

No (447)

337 (20.7)

110 (15.8)

 

12.70

104 (15.9)

104 (15.9)

 

0.00

Yes (1877)

1290 (79.1)

587 (84.2)

 

-13.15

549 (83.9)

550 (84.1)

 

-0.42

Missing data (3)

3 (0.2)

0 (0.0)

 

6.07

1 (0.2)

0 (0.0)

 

5.53

Pathologic T status

  

< 0.0001

   

0.8647

 

T1 (299)

146 (9.0)

153 (22.0)

 

-36.54

121 (18.5)

123 (18.8)

 

-0.79

T2 (641)

410 (25.2)

231 (33.1)

 

-17.65

217 (33.2)

222 (33.9)

 

-1.62

T3 (402)

294 (18.0)

108 (15.5)

 

6.81

117 (17.9)

106 (16.2)

 

4.47

T4 (985)

780 (47.8)

205 (29.4)

 

38.57

199 (30.4)

203 (31.1)

 

-1.33

Pathologic N status

  

< 0.0001

   

0.8308

 

pN0 (1107)

672 (41.2)

435 (62.4)

 

-43.38

388 (59.3)

397 (60.7)

 

-2.81

pN1 (258)

185 (11.3)

73 (10.5)

 

2.81

75 (11.5)

72 (11.0)

 

1.45

pN2 (379)

272 (16.7)

107 (15.4)

 

3.64

101 (15.4)

103 (15.7)

 

-0.84

pN3 (583)

501 (30.8)

82 (11.7)

 

47.68

90 (13.8)

82 (12.6)

 

3.62

Pathologic stage

  

< 0.0001

   

0.8650

 

I (236)

110 (6.7)

126 (18.1)

 

-34.88

96 (14.7)

97 (14.8)

 

-0.43

II (368)

225 (13.8)

143 (20.5)

 

-17.88

127 (19.4)

137 (20.9)

 

-3.81

III (339)

224 (13.7)

115 (16.5)

 

-7.7

119 (18.2)

112 (17.1)

 

3.00

IV (1384)

1071 (65.8)

313 (44.9)

 

42.78

312 (47.7)

308 (47.2)

 

2.81

Tumor differentiation

  

< 0.0001

   

0.7250

 

Well (445)

257 (15.8)

188 (27.0)

 

-27.6

168 (25.7)

163 (24.9)

 

1.76

Moderately (1536)

1089 (66.8)

447 (64.1)

 

5.63

417 (63.8)

429 (65.6)

 

-3.84

Poorly (344)

282 (17.3)

62 (8.9)

 

25.11

69 (10.5)

62 (9.5)

 

3.57

Undifferentiated (2)

2 (0.1)

0 (0.0)

 

4.96

0 (0.0)

0 (0.0)

 

0.00

Depth of invasion

  

< 0.0001

   

0.7355

 

< 10 mm (933)

546 (33.5)

387 (55.5)

 

-45.45

340 (52.0)

345 (52.8)

 

-1.53

≥ 10 mm (1394)

1084 (66.5)

310 (44.5)

 

45.45

314 (48.0)

309 (47.2)

 

1.53

Margin status

  

0.0902

   

0.9524

 

< 5 mm (1304)

932 (57.2)

372 (53.4)

 

7.66

356 (54.4)

357 (54.6)

 

-0.31

≥ 5 mm (1023)

698 (42.8)

325 (46.6)

 

-7.66

298 (45.6)

297 (45.4)

 

0.31

Extranodal extension

  

< 0.0001

   

0.6042

 

No (1641)

1055 (64.7)

586 (84.1)

 

-45.47

538 (82.3)

544 (83.2)

 

-2.43

Yes (686)

575 (35.3)

111 (15.9)

 

45.47

116 (17.7)

110 (16.8)

 

2.43

Treatment modality

  

< 0.0001

   

0.2414

 

 S alone (841)

541 (33.2)

300 (43.0)

 

-20.39

252 (38.5)

271 (41.4)

 

-5.93

S plus CT + S plus RT

+ S plus CT and RT (1486)

1089 (66.8)

397 (57.0)

 

20.39

402 (61.5)

383 (58.6)

 

5.93

Distant relapse

  

< 0.0001

   

0.8563

 

No (1653)

1064 (65.3)

589 (84.5)

 

-45.47

548 (83.8)

546 (83.5)

 

0.83

Yes (674)

566 (34.7)

108 (15.5)

 

45.47

106 (16.2)

108 (16.5)

 

-0.83

Time interval (days)

        

Range

14–330

331–2128

      

Median

173

775

      

Mean

174

886

      

RT technique in the S + RT subgroup (n = 342)

  

0.1996

     

Conformal (10)

6 (2.6)

4 (3.5)

      

IMRT (169)

105 (46.3)

64 (55.7)

      

VMAT (163)

116 (51.1)

47 (40.9)

      

RT dose (cGy) in the S + RT subgroup (n = 342)

        

Range (200–8200)

200–8200

1000–7050

      

Median (6000)

6000

6050

0.8214c

     

Mean (5959.9)

5875.0

6127.4

      

 S-RT interval in the S + RTsubgroup (n = 342)

        

Range (14–146 days)

14–146

15–79

      

Median (37 days)

37

37

0.5410c

     

Mean (38.6 days)

39.3

37.1

      

RT Technique in the S + CT + RT subgroup

(n = 1071)

  

0.0537

     

Conformal (17)

15 (1.9)

2 (0.8)

      

IMRT (531)

384 (47.6)

147 (55.5)

      

VMAT (523)

407 (50.5)

116 (43.8)

      

RT dose (cGy) in the S + CT + RT subgroup

(n = 1071)

        

Range (600–8700)

600–7800

600–8700

      

Median (6600)

6600

6600

0.3324c

     

Mean (6414.0)

6403.2

6446.6

      

 S-RT interval in the S + CT + RT subgroup

(n = 1071)

        

Range (13–211 days)

14–211

13–162

      

Median (38 days)

38

37

0.1593c

     

Mean (40.7 days)

40.5

41.5

      

RT field in pN0 (n = 378)

  

0.9584

     

Primary tumor + neck (106)

65 (28.1)

41 (27.9)

      

Primary tumor only (272)

166 (71.9)

106 (72.1)

      
  1. SMD standardized mean difference, S surgery, CT chemotherapy, RT radiotherapy, IMRT intensity modulated radiation therapy, VMAT Volumetric-modulated arc therapy
  2. a Chi-square test; b McNemar test; c Mann-Whitney U Test (skewed data)
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