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Fig. 2 | BMC Cancer

Fig. 2

From: Screening and identification of miR-181a-5p in oral squamous cell carcinoma and functional verification in vivo and in vitro

Fig. 2

(A-C) Volcano plot of dysregulated miRNAs: (A) Simple hyperplasia group; (B) Abnormal hyperplasia group, and (C) Squamous cell carcinoma group; Vertical axis correspond to –log(padj). Horizontal axis represents log2 (fold change). The red and blue dots represent upregulated and downregulated miRNAs, respectively. (D-F) Heatmap of differentially expressed miRNAs: (D) Simple hyperplasia group; (E) Abnormal hyperplasia group; and (F) Squamous cell carcinoma group. (G-I) GO classification of the target genes: (G) Simple hyperplasia group; (H) Abnormal hyperplasia group; and (I) Squamous cell carcinoma group. (J-K) KEGG analysis of the target genes: (J) Top 15 significantly enriched pathways between the simple hyperplasia and Squamous cell carcinoma groups; (K) Top 15 significantly enriched pathways between the simple hyperplasia stage and Squamous cell carcinoma groups. The colors indicate the FDR value of the pathways

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