Table 3 Correlation of central lymph node metastasis and clinicopathological features
Characteristics | Overall N(%) | Nonmetastasis N(%) | Metastasis N(%) | X2 | P -value |
|---|---|---|---|---|---|
Sample size | 477 | 251 | 226 | Â | Â |
Sex | |||||
 Male | 124 (26.0) | 56 (22.3) | 68 (30.0) | 3.739 | 0.053 |
 Female | 353 (74.0) | 195 (77.7) | 158 (70.0) | ||
Age (years) | |||||
  < 45 | 234 (49.1) | 88 (35.1) | 146 (64.6) | 41.530 |  < 0.001 |
  ≥ 45 | 243(50.9) | 163 (64.9) | 80 (35.4) | ||
Combined benign thyroid disease | |||||
 No | 257 (53.9) | 128 (51.0) | 129 (57.1) | 5.803 | 0.122 |
 Nodular goiter | 133 (27.9) | 73 (29.1) | 60 (26.5) | ||
 Lymphocytic thyroiditis | 66 (13.8) | 34 (13.5) | 32 (14.2) | ||
 Both | 21 (4.4) | 16 (6.4) | 5 (2.2) | ||
Surgical method | |||||
 Unilateral | 230 (48.2) | 123 (49.0) | 107 (47.3) | 0.073 | 0.787 |
 Total | 247 (51.8) | 128 (51.0) | 119 (52.7) | ||
BRAF V600E gene mutation | |||||
 No | 97 (20.3) | 80 (31.9) | 17 (7.5) | 43.527 |  < 0.001 |
 Yes | 380 (79.7) | 171 (68.1) | 209 (92.5) | ||
Maximum diameter of thyroid nodules | |||||
  < 10 mm | 207 (43.4) | 137 (54.6) | 70 (31.0) | 33.497 |  < 0.001 |
 10–20 mm | 201 (42.1) | 94 (37.4) | 107 (47.3) | ||
  > 20 mm | 69 (14.5) | 20(8.0) | 49 (21.7) | ||
Nodule location | |||||
 Upper 1/3 | 98 (20.6) | 53 (21.1) | 45 (19.9) | 1.756 | 0.781 |
 Middle 1/3 | 145 (30.4) | 79 (31.5) | 66 (29.2) | ||
 Lower 1/3 | 76 (15.9) | 36 (14.3) | 40 (17.7) | ||
 Isthmus | 62 (13.0) | 35 (14.0) | 27 (12.0) | ||
 Whole | 96 (20.1) | 48 (19.1) | 48 (21.2) | ||
Aspect Ratio | |||||
  < 1 | 274 (57.4) | 139 (55.4) | 135 (59.7) | 0.923 | 0.337 |
  ≥ 1 | 203 (42.6) | 112 (44.6) | 91 (40.3) | ||
Microcalcification | |||||
 No | 123 (25.8) | 72 (28.7) | 51 (22.6) | 2.327 | 0.127 |
 Yes | 354 (74.2) | 179 (71.3) | 175 (77.4) | ||
Nodule boundary | |||||
 Clear | 192 (40.3) | 108 (43.0) | 84 (37.2) | 1.698 | 0.193 |
 Blurred | 285 (59.7) | 143 (57.0) | 142 (62.8) | ||
Capsular invasion | |||||
 No | 268 (56.2) | 153 (61.0) | 115 (50.9) | 13.055 | 0.001 |
 Close | 63 (13.2) | 39 (15.5) | 24 (10.6) | ||
 Invasion | 146 (30.6) | 59 (23.5) | 87 (38.5) | ||
Number of lesions | |||||
 Unifocal | 339 (71.1) | 186 (74.1) | 153 (67.7) | 2.372 | 0.123 |
 Multifocal | 138 (28.9) | 65 (25.9) | 73 (32.3) | ||
ACR-TIRADS classification | |||||
 3 | 19 (4.00) | 7 (2.79) | 12 (5.31) | 5.711 | 0.335 |
 4a | 268 (56.2) | 147 (58.57) | 121 (53.54) | ||
 4b | 149 (31.2) | 72 (28.69) | 77 (34.07) | ||
 4c | 27 (5.66) | 18 (7.17) | 9 (3.98) | ||
 5 | 12 (2.52) | 6 (2.39) | 6 (2.66) | ||
 6 | 2 (0.42) | 1 (0.39) | 1 (0.44) | ||