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Fig. 5 | BMC Cancer

Fig. 5

From: LncRNA ANRIL promotes HR repair through regulating PARP1 expression by sponging miR-7-5p in lung cancer

Fig. 5

Promote of the HR repair pathway by ANRIL/miR-7-5p/PARP1 axis in lung cancer cells. a Western blot experiments detected the protein expression changes of PARP1, BRCA1 and RAD51 in ANRIL knockdown cells after ionizing radiation. b-c Immunofluorescence assays detected the foci recruitment of BRCA1 and Rad51 in ANRIL knockdown cells after ionizing radiation. d Cell growth after ionizing radiation were assayed in NC-, ANRIL-OE-, ANRIL-OE + siRNA-NC- and ANRIL-OE + siRNA-PARP1-transfected H460 cells by CCK-8 assays. e A working model of ANRIL promoting HR repair after ionizing radiation. ANRIL upregulation promotes HR repair after DNA damage by targeting the miR-7-5p/PARP1/BRCA1/RAD51 axis, conferring lung cancer cells resistant to radiotherapy. *p < 0.05; **p < 0.01

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BMC Cancer

ISSN: 1471-2407

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