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Fig. 3 | BMC Cancer

Fig. 3

From: LncRNA ANRIL promotes HR repair through regulating PARP1 expression by sponging miR-7-5p in lung cancer

Fig. 3

ANRIL inhibits radiosensitivity of lung cancer cells by targeting miR-7-5p. a-b, e Cell growth and viability after ionizing radiation were assayed in NC-, shANRIL-, shANRIL + inhibitor-NC- and shANRIL + inhibitor-miR-7-5p-transfected H1299 cells by CCK-8 assays and clone formation. c-d The apoptosis after ionizing radiation was detected in NC-, shANRIL-, shANRIL + inhibitor-NC- and shANRIL + inhibitor-miR-7-5p-transfected H1299 cells by flow cytometry. f ANRIL was mutated at the putative binding site. Luciferase activity in 293 T cells co-transfected with mimic-NC or mimic-miR-7-5p and luciferase reports containing NC, ANRIL-wt or ANRIL-mut transcripts. The results are presented as relative ratio of firefly luciferase activity to Renilla luciferase activity. *p < 0.05; **p < 0.01; ***p < 0.001

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