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Table 1 Recurrence and Local Control Events for Basal Cell Carcinoma (BCC), Squamous Cell Carcinoma (SCC) and Squamous Cell Carcinoma In Situ (SCCIS) with High resolution dermal ultrasound image guided superficial radiotherapy (US-SRT) versus External Radiation Therapy (XRT) / Superficial Radiation Therapy (SRT) Contrasts Using Odds Ratios (OR)

From: High resolution dermal ultrasound (US) combined with superficial radiation therapy (SRT) versus non-image guided SRT or external beam radiotherapy (XRT) in early-stage epithelial cancer: a comparison of studies

Lesion

Treatment

Study

Outcome

Odds Ratio (XRT/SRT over US-SRT) (95% Confidence Limits)

Recurrence

Local Control

(n)

(%)

(n)

Yu 2021: US-SRT

Moloney 2022: US-SRT

BCC

US-SRT

Yu (2021)

6

0.9

698

OR

p-value

OR

p-value

Moloney (2022)

16

1.1

1471

XRT/SRT

Lovett

20

9.0

202

11.5

(4.6, 29.1)

ā€‰<ā€‰.0001

9.1

(4.6, 17.9)

ā€‰<ā€‰.0001

Locke

21

6.4

305

8.0

(3.2, 20.0)

ā€‰<ā€‰.0001

6.3

(3.3, 12.3)

ā€‰<ā€‰.0001

Silverman

52

6.0

810

7.5

(3.2, 17.5)

ā€‰<ā€‰.0001

5.9

(3.3, 10.4)

ā€‰<ā€‰.0001

Cognetta

22

3.1

690

3.7

(1.5, 9.2)

0.0047

2.9

(1.5, 5.6)

0.0012

All

115

5.4

2007

7.1

(3.1,16.3)

ā€‰<ā€‰.0001

5.6

(3.3, 9.6)

ā€‰<ā€‰.0001

SCC

US-SRT

Yu (2021)

4

0.7

544

OR

p-value

OR

p-value

Moloney (2022)

7

0.8

926

XRT/SRT

Lovett

14

18.9

60

31.7

(10.1, 99.5)

ā€‰<ā€‰.0001

30.9

(12.0, 79.3)

ā€‰<ā€‰.0001

Locke

15

15.2

84

24.3

(7.9, 74.9)

ā€‰<ā€‰.0001

23.6

(9.4, 59.5)

ā€‰<ā€‰.0001

Cognetta

4

3.0

129

4.2

(1.0, 17.1)

0.0438

4.1

(1.2, 14.2)

0.0259

All

33

10.8

273

14.8

(5.1, 43.3)

ā€‰<ā€‰.0001

14.4

(6.1, 33.9

ā€‰<ā€‰.0001

SCCIS

US-SRT

Yu (2021)

2

0.5

415

OR

p-value

OR

p-value

Moloney (2022)

1

0.2

649

XRT/SRT

Cognetta

19

2.2

842

4.7

(1.1, 20.2)

0.0385

14.6

(2.0, 109.7)

0.0090

  1. Silverman presented 2-year and 5-year follow-up results. Mean 5-year follow-up was used. Mean follow-up for Yu, Moloney, Lovett, Locke, and Cognetta, respectively, was 2Ā·1, 2Ā·1, 5, 5 and 2Ā·6Ā years. Silverman presented no SCC data. Only Cognetta presented SCCIS