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Fig. 6 | BMC Cancer

Fig. 6

From: Histone methyltransferase SETD1A interacts with notch and promotes notch transactivation to augment ovarian cancer development

Fig. 6

SETD1A increases H3K4me3 levels at the promoters of Hes1 to enhance Notch transactivation. A-C The recruitments of Notch1 A, SETD1A B, and the H3K4me3 levels C at Hes1 promoter in JAG overexpression SKOV3 cells analyzed by ChIP assays. Unpaired two-tailed t-test. Data are expressed as mean ± SD. **p < 0.01, ***p < 0.001. D-F The recruitments of SETD1A D and Notch F, and the H3K4me3 levels E at Hes1 promoters in SETD1A knockdown SKOV3 cells analyzed by ChIP assays. Unpaired two-tailed t-test. Data are expressed as mean ± SD. **p < 0.01, ***p < 0.001. G The protein levels of Notch1 and its target genes (Hes1, Hey1, Hey2 and Heyl) in JAG1 overexpressed SETD1A knockdown SKOV3 cells analyzed by western blotting assays. H-J The recruitments of Notch1 H, SETD1A I and the H3K4me3 levels J at Hes1 promoters in JAG1 overexpressed SETD1A knockdown SKOV3 cells analyzed by ChIP assays. Unpaired two-tailed t-test. Data are expressed as mean ± SD. **p < 0.01, ***p < 0.001, ****p < 0.0001

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