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Fig. 3 | BMC Cancer

Fig. 3

From: Histone methyltransferase SETD1A interacts with notch and promotes notch transactivation to augment ovarian cancer development

Fig. 3

SETD1A augments OV cell migration and invasion and metastasis. A The cell wound healing of SETD1A overexpression RMGI and OVCAR5 cells analyzed by wound healing assays. Unpaired two-tailed t-test. Data are expressed as mean ± SD. **p < 0.01. B The cell wound healing of SETD1A knockdown SKOV3 and Caov3 cells analyzed by wound healing assays. Unpaired two-tailed t-test. Data are expressed as mean ± SD. **p < 0.01, ***p < 0.001. C,D The cell migration and invasion of SETD1A overexpression RMGI C and OVCAR5 D cells analyzed by transwell assays. Unpaired two-tailed t-test. Data are expressed as mean ± SD. **p < 0.01, ****p < 0.0001. E,F The cell migration and invasion of SETD1A knockdown SKOV3 E and Caov3 F cells analyzed by transwell migration and invasion. Unpaired two-tailed t-test. Data are expressed as mean ± SD. **p < 0.01, ***p < 0.001, ****p < 0.0001. (the scale bar = 100 μm)

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