Characteristic | All patients(n = 211) | 1st line(n = 85) | 2nd line(n = 78) | ≥ 3rd line(n = 48) |
---|---|---|---|---|
Median age, years (range) | 53(29–88) | 55(29–84) | 51(32–88) | 53(29–57) |
 ≥65y | 41(19.4) | 18(21.2) | 17(21.8) | 6(12.5) |
 <65y | 170(80.6) | 67(78.8) | 61(78.2) | 42(87.5) |
Menstruation status | Â | Â | Â | Â |
 Menopausal | 141(67.1) | 58(69.0) | 53(67.9) | 30(62.5) |
 Premenopausal | 70(32.9) | 27(31.0) | 25(32.1) | 18(37.5) |
ECOG PS | Â | Â | Â | Â |
 0 | 73(34.6) | 29(34.1) | 30(38.5) | 14(29.1) |
 1 | 130(61.6) | 53(62.4) | 45(57.7) | 32(66.7) |
 2 | 8(3.8) | 3(3.5) | 3(3.8) | 2(4.2) |
IV stage of first diagnosis | Â | Â | Â | Â |
 Yes | 50(23.7) | 27(31.8) | 12(15.4) | 11(22.9) |
 No | 161(76.3) | 58(68.2) | 66(84.6) | 37(77.1) |
Hormone receptor status | Â | Â | Â | Â |
 ER + PgR+ | 165(78.2) | 71(83.5) | 57(73.1) | 37(77.1) |
 ER + PgR- | 46(21.8) | 14(16.5) | 21(26.9) | 11(22.9) |
ER status | Â | Â | Â | Â |
 ≥ 50% | 182(86.3) | 70(82.4) | 70(89.7) | 42(87.5) |
 <50% | 29(13.7) | 15(17.6) | 8(10.3) | 6(12.5) |
Sensitivity to ET | Â | Â | Â | Â |
 Sensitivity | 94(44.6) | 53(62.4) | 26(33.3) | 15(31.3) |
 Acquired resistance | 92(43.6) | 28(32.9) | 39(50.0) | 25(52.0) |
 Primary resistance | 25(11.8) | 4(4.7) | 13(16.7) | 8(16.7) |
Number of metastatic sites | Â | Â | Â | Â |
 ≥3 | 69(32.7) | 20(23.5) | 28(35.9) | 21(43.7) |
 <3 | 142(67.3) | 65(76.5) | 50(64.1) | 27(56.3) |
Presence of visceral metastasis | Â | Â | Â | Â |
 Yes | 134(63.5) | 44(51.8) | 52(66.7) | 38(79.2) |
 No | 77(36.5) | 41(48.2) | 26(33.3) | 10(20.8) |
Metastatic sites | Â | Â | Â | Â |
 Bone only | 42(19.9) | 20(23.5) | 16(20.5) | 6(12.5) |
 Lung involvement | 72(34.1) | 25(29.4) | 27(34.6) | 20(41.7) |
 Liver involvement | 78(37.0) | 24(28.2) | 29(37.2) | 25(52.1) |
 Brain involvement | 15(7.1) | 3(3.5) | 6(7.7) | 6(12.6) |
 Bone marrow | 3(1.4) | 2(2.4) | 1(1.3) | - |
Concomitant ET | Â | Â | Â | Â |
 FULV | 95(45.0) | 35(41.2) | 43(55.1) | 17(35.4) |
 AI | 112(53.1) | 47(55.3) | 34(43.6) | 31(64.6) |
 TAM/TORE | 4(1.9) | 3(3.5) | 1(1.3) | - |