Fig. 6From: IGF-1R down regulates the sensitivity of hepatocellular carcinoma to sorafenib through the PI3K / akt and RAS / raf / ERK signaling pathwaysDownregulating the expression or activation of IGF-1R restored the antitumor effect of sorafenib in vivo. (A) The end-point tumor volume (mm3) of nude mice in each group was determined. (B) The body weight (g) of mice in each group was recorded every 3 daysBack to article page