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Fig. 5 | BMC Cancer

Fig. 5

From: IGF-1R down regulates the sensitivity of hepatocellular carcinoma to sorafenib through the PI3K / akt and RAS / raf / ERK signaling pathways

Fig. 5

IGF-1R signaling regulates HCC resistance to sorafenib by activating PI3K/Akt and Ras/Raf/ERK pathways. (A, B) Changes of key kinases in IGF-1R/p-IGF-1R, PI3K/Akt and Ras/Raf/ERK pathways in each treatment group. (C, D) The levels of cleaved caspase 3 and cleaved PARP were detected by Western blot. The reference of each protein is β-actin

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BMC Cancer

ISSN: 1471-2407

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