Fig. 8From: GDNF-RET signaling and EGR1 form a positive feedback loop that promotes tamoxifen resistance via cyclin D1Proposed GDNF-RET-EGR1 tamoxifen resistance mechanism in ERα + breast cancer. A Graphical summary of the GDNF-RET-EGR1 tamoxifen resistant mechanism in ERα+ breast cancer where GDNF-RET-EGR1 signaling forms a positive feedback loop and promotes cell cycle progression through cyclin D1 upregulationBack to article page