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Fig. 5 | BMC Cancer

Fig. 5

From: GDNF-RET signaling and EGR1 form a positive feedback loop that promotes tamoxifen resistance via cyclin D1

Fig. 5

Mechanism of GDNF-EGR1 positive feedback loop. A UCSC genome browser data showing p-ELK-1 binding motif located at EGR1 promoter. B ChIP-qPCR data showing increased p-ELK-1 binding after rGDNF treatment. C UCSC genome browser data showing EGR1 binding motif located at the GDNF promoter. D ChIP-qPCR data showing increased EGR1 binding to the GDNF promoter. *p < 0.05, **p < 0.005. Student’s paired t-test was used for statistical analyses

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