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Table 4 Competing risks regression of seizures by phenotype and with/without seizure history

From: Risk of seizures in a population of women with BRCA-positive metastatic breast cancer from an electronic health record database in the United States

Phenotype

Overall (nĀ =ā€‰5911)

With seizure history (nĀ =ā€‰616)

Without seizure history (nĀ =ā€‰5295)

History of anticonvulsant use (nĀ =ā€‰1690)

History of brain metastasis

(nĀ =ā€‰818)

HR

95% CI

HR

95% CI

HR

95% CI

HR

95% CI

HR

95% CI

HER2āˆ’/HR+

1.00

Ref.

1.00

Ref.

1.00

Ref.

1.00

Ref.

1.00

Ref.

HER2+/HR-

1.29**

(1.07, 1.56)

0.75

(0.49, 1.16)

1.38**

(1.12, 1.71)

1.45*

(1.07, 1.96)

1.01

(0.79, 1.30)

HER2+/HR+

1.10

(0.97, 1.26)

1.00

(0.77, 1.31)

1.12

(0.97, 1.30)

1.05

(0.82, 1.33)

1.04

(0.90, 1.22)

TNBC

1.35***

(1.21, 1.52)

0.99

(0.78, 1.26)

1.40***

(1.23, 1.60)

1.05

(0.85, 1.30)

1.12

(0.97, 1.29)

  1. Note: Adjusted for age at metastasis, number of prior lines of therapy, and site of metastasis
  2. * pĀ <ā€‰0.05, ** pĀ <ā€‰0.01, *** pĀ <ā€‰0.001