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Table 2 Characteristics of Patients in the training set and P value of univariate analysis. Factors with statistical significance include tumor location, size, Clinical T stage, Clinical N stage, differentiation, Smoking history

From: Risk model and factors for prediction of response to neoadjuvant chemotherapy in patients with advanced gastric cancer-a two-center cohort study

Characteristics

effective group (CR/PR)n = 162(%)

ineffective group (PD/SD)n = 145(%)

t/χ2

P

Age

59.64 ± 10.02

59.06 ± 11.25

−0.41

0.684

Sex

Male

109 (67.28)

95 (65.52)

0.107

0.743

Female

53 (32.72)

50 (34.48)

BMI

22.32 (20.46–24.82)

22.49 (20.20–24.24)

−0.66

0.513

Location

Esophagogastric junction

79 (48.77)

32 (22.07)

23.624

< 0.001

Non-Esophagogastric junction

83 (51.23)

113 (77.93)

Tumor size, cm

5.30 ± 2.25

6.44 ± 3.19

3.11

0.002

Tumor differentiation

Well+Moderately differentiated

87 (53.70)

27 (18.62)

40.342

< 0.001

Poorly differentiated+

Signet ring cell

75 (46.30)

118 (81.38)

cT stage

T2 + T3

74 (45.68)

21 (14.48)

34.847

< 0.001

T4

88 (54.32)

124 (85.52)

cN stage

N0

57 (35.19)

10 (6.90)

35.889

< 0.001

N+

105 (64.81)

135 (93.10)

Borrmann classification

I + II

52 (32.10)

36 (24.83)

1.978

0.160

III + IV

110 (67.90)

109 (75.17)

Blood type

Type A

50 (30.86)

40 (27.59)

1.701

0.637

Type B

50 (30.86)

39 (26.90)

Type AB

15 (9.26)

17 (11.72)

Type O

47 (29.01)

49 (33.79)

CEA, ng/mL

6.5 ± 17.06

19.43 ± 99.23

1.30

0.198

CA724, U/mL

3.53 (1.50–10.63)

2.94 (1.88–12.83)

0.15

0.880

CA125, U/mL

13.98 ± 7.79

13.91 ± 9.20

−0.60

0.952

CA199, U/mL

37.45 ± 115.07

38.70 ± 97.23

0.09

0.930

Albumin, g/L

42.10 ± 3.52

41.24 ± 4.04

−1.72

0.086

PLT, 109/L

212.03 ± 76.3

226.41 ± 90.12

1.31

0.192

Lymphocyte, 109/L

1.58 ± 0.46

1.57 ± 0.47

0.07

0.945

PLR

134.00 (94.38–182.86)

136.99 (104.91–182.79)

0.88

0.382

Neutrophil cell, 109/L

3.57 ± 1.33

3.64 ± 1.45

0.35

0.724

Monocyte, 109/L

0.43 ± 0.16

0.40 ± 0.14

−1.37

0.173

NMR

8.23 (6.52–10.57)

8.97 (6.83–11.29)

0.92

0.360

NLR

2.22 (1.56–2.92)

2.28 (1.68–2.78)

0.18

0.860

MSI

H

13 (8.02)

9 (6.21)

0.380

0.538

S/L

149 (91.98)

136 (93.79)

Smoking history

yes

44 (27.16)

69 (47.59)

13.724

< 0.001

no

118 (72.84)

76(52.41)

  1. BMI Body Mass Index; CA125 Carbohydrate antigen 125; CEA Carcinoembryonic antigen; CA724 Carbohydrate antigen 724; CA125 Carbohydrate antigen 125; CA199 Carbohydrate antigen 199; PLT Platelets; PLR platelet to lymphocyte ratio; NMR neutrophil to monocyte ratio; NLR neutrolphil to lymphocyte ratio; MSI microsatellite instability