Table 1 Systemic mastocytosis criteria

Major Criterion^a

 -Multifocal dense mast cells in the bone marrow or other extra-skin organs

infiltration (presence of more than 15 mast cells in aggregates)

Minor Criteria^a

 -Abnormal mast cells in bone marrow or other extra-skin organs (>%25)

 -Presence of Asp-816-Val c-KIT mutation in extra skin organs^b

 -CD2 and CD25 positivity in bone marrow mast cells

 -Serum tryptase level > 20 ng / mL (not applied in the presence of hematological clonal disease)