Fig. 1

Analysis of TAP1 at the genetic, RNA, and protein levels. A RNA expression of TAP1 in tumor and normal tissues from 27 pan-cancer types. B Comparison of differential TAP1 RNA expression in GBM and NBT. C Comparison of TAP1 protein expression between cancerous and adjacent normal tissue from patients with GBM, the full-length blots/gels are presented in Supplemental Fig. 1. D Differences in TAP1 expression within paired clinical GBM samples (n = 7 pairs, p value = 0.0042). E Genomic alterations of TAP1 across pan-cancer presented as types and frequencies of alterations. F Correlation between TAP1 expression and copy number variation at the pan-cancer scale. G Analysis of correlation between copy number variation and TAP1 expression level in KICH. H Distribution of TAP1 protein in the HaCaT and SKMEL30 cell lines; HaCaT is human non-malignant keratinocyte line and SKMEL30 is human melanoma cell line. I Protein–protein interactions of TAP1 in different cellular structures. GBM, glioblastoma; NBT, normal brain tissue; KICH, Kidney Chromophobe. *P < 0.05, **P < 0.01, ***P < 0.001