Fig. 8

Two representative examples of indolent and aggressive false negative prediction. These output were obtained on whole slide images (WSIs) from core needle biopsy test set using the model (TL-Colon poorly ADC (x20, 512) and FS+WS). Histopathologically, in (A), infiltration of adenocarcinoma which exhibited Gleason pattern 3 was observed only in a limited area (C) of the #1 fragment where pathologist marked a red ink-dot on the glass slide. There was no evidence of malignancy in #2-#10 fragments (A). The heatmap image (B) show a true positive prediction of indolent on the Gleason pattern 3 adenocarcinoma (C) with very low probability (D). The prediction output at WSI level was benign (B). Histopathologically, in (E), there were a few fragmented adenocarcinoma foci with cribriform pattern which exhibited Gleason pattern 4 (G) in the #2 fragment. The heatmap image (F) show a true positive prediction of aggressive on a few adenocarcinoma (G) with very low probability (H). The prediction output at WSI level was benign (F). The heatmap uses the jet color map where blue indicates low probability and red indicates high probability