Fig. 5

Two representative examples of indolent and aggressive true positive prediction. These outputs were obtained on whole slide images (WSIs) from core needle biopsy test set using the model (TL-Colon poorly ADC (x20, 512) and FS+WS). In the WSI of core needle biopsy specimen (A), histopathologically, adenocarcinoma corresponded with Gleason score 3+3 (C) infiltrated in both #1 and #2 fragments. The heatmap image (B) shows true positive indolent predictions (B, D) which correspond respectively to H &E histopathology (C, D). Histopathologically, in (E), #1 and #2 fragments were benign (non-neoplastic) lesions. Prostate adenocarcinoma which form small fused glands (G) corresponded with Gleason score 4+4 infiltrated in #3 and #4 fragments. The heatmap image (F) shows true positive aggressive predictions (F, H) which correspond respectively to H &E histopathology (E, G). The heatmap uses the jet color map where blue indicates low probability and red indicates high probability