Fig. 2
From: Inference of core needle biopsy whole slide images requiring definitive therapy for prostate cancer
Representative images with manually-drawn annotations for Gleason pattern 3, 4, and 5 of adenocarcinoma. We performed annotations for well-formed glands with intraluminal crystalloids (Gleason pattern 3) (A), large irregular cribriform glands (Gleason pattern 4) (B), crowded fused glands (Gleason pattern 4) (C), poorly formed small-sized glands with some lumen-formation (Gleason pattern over 4) (D), ductal adenocarcinoma lined by columnar cells with elongated nuclei (Gleason pattern 4) (E), and infiltrating cords and single tumor cells without lumen formation (Gleason pattern 5) (F). We did not annotate areas where it was difficult to determine cytologically that the lesions were cancerous