Mendelian randomization study of causal link from gut microbiota to colorectal cancer

BMC Cancer

Table 2 SNPs detailed information of genus Blautia and colorectal cancer in the discovery and replication cohorts

Stage	SNP	Chr	Position	Locus	A1	A0	Closest gene	Exposure (genus Blautia)			Outcome (colorectal cancer)
Stage	SNP	Chr	Position	Locus	A1	A0	Closest gene	Beta	SE	P-value	Beta	SE	P-value
Discovery
	rs17862118	7	89,820,804	7q21.13	C	T	STEAP2	-3.00	0.578	2.40 × 10^− 7	0.059	0.030	0.05
	rs1986785	13	30,029,722	13q12.3	C	A	MTUS2	-2.27	0.428	1.30 × 10^− 7	0.021	0.022	0.35
	rs4673912	2	201,168,993	2q33.1	T	G	SPATS2L	1.23	0.249	8.34 × 10^− 7	-0.009	0.022	0.70
	rs6929224	6	37,746,848	6p21.2	C	T	ZFAND3	2.52	0.050	4.28 × 10^− 7	0.015	0.031	0.63
Replication
	rs4669413	2	9,805,923	2p25.1	T	C	YWHAQ	-0.18	0.032	1.20 × 10^− 8	0.040	0.022	0.07
	rs79387448	2	103,215,410	2q12.1	C	T	SLC9A2	-0.31	0.048	7.68 × 10^− 11	0.048	0.029	0.10

Chr is Chromosome of SNP. Physical position is based on the human genome GRCH37 assembly. A1 is the effect allele and A0 is the other allele. Beta is the estimate coefficient of the effect allele. SE is the standard error of estimate coefficient. Closest gene is the closest gene to which the SNP mapped

ISSN: 1471-2407