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Table 1 Review of reports on tumor infiltrating lymphocytes

From: Primary head and neck cancer cell cultures are susceptible to proliferation of Epstein-Barr virus infected lymphocytes

Cancer type

TIL + cases (% of total cases, number of total cases)

Features of TIL

Prognostic population

EBV status

Reference

HNSCC

100% (n = 40)

c T11+, T4+ or T8+

Rare B1+ or Leu 7+

T8+ cell

N.T

[32]

89% of HPV+ cases (17/19)

56% to 64% in the rest;

136 cases totally

c CD3+, CD8+, CD20+

CD3+ T cell

N.T

[30]

100% (n = 50)

c CD20+ B cell

Peritumoral CD20+ cell

N.T

[33]

c 98.8% (n = 85)

Not mentioned

Not mentioned

N.T

[34]

100% (n = 5)

a CD3+ T cell with CD4+ or CD8+

Not mentioned

N.T

[39]

b17.8% (8/45 total cases); 50% (8/16 xenografts)

bCD20+ cell

partially with CD3+ cells

Not mentioned

8 EBV+ cases

[38]

Lung cancer

1/1

unknown

Not mentioned

N.T

[42]

93.75% (n = 32)

(Brain metastasis)

c。CD3+ T cell, CD8+, FoxP3+

Not mentioned

N.T

[35]

16.2% (n = 155)

c CD3+ T cell, CD20+ B cell

CD3+ cell, CD45+ cell, CD20+ cell

N.T

[52]

Brest cancer

29.2% (n = 788)

c B cell, T cell

B cell

N.T

[36]

1/1

a CD3+ T cell with CD4+ or CD8+

Not mentioned

N.T

[40]

1/1

a CD3+ T cell with CD4+ or CD8+

Not mentioned

N.T

[42]

64.4% (n = 90) CD3+

24.4% (n = 90) CD20+

c B cell, T cell

Not mentioned

N.T

[31]

Cervical and ovarian cancer

1/1

a CD3+ T cell with CD4+ or CD8+

Not mentioned

N.T

[40]

2/2

a CD3+ T cell with CD4+ or CD8+

Not mentioned

N.T

[42]

100% (n = 18)

a CD3+ T cell with CD4+ or CD8+

Not mentioned

N.T

[39]

Gastrointestinal cancer

1/1

a CD3+ T cell with CD4+ or CD8+

Not mentioned

N.T

[42]

Colorectal cancer

100% (n = 67)

c 100% with CD4+ CD8+

53.7% with CD20+

Not mentioned

N.T

[37]

1/1

a CD3+ T cell with CD8+ or CD25+

Not mentioned

N.T

[40]

2/2

a CD3+ T cell with CD4+ or CD8+

Not mentioned

N.T

[42]

38.3% (n = 47)

bCD45+ cells with CD20+

Not mentioned

12 EBV + cases

[5]

100% (n = 5)

a CD3+ T cell with CD4+ or CD8+

Not mentioned

N.T

[39]

Pancreatic ductal adenocarcinomas

32.4% (n = 37)

bCD45+ cells with CD20+

Not mentioned

4 EBV + cases

[5]

Urinary system cancer

100% (n = 9)

a CD3+ T cell with CD4+ or CD8+

Not mentioned

N.T

[40]

1/1

a CD3+ T cell with CD4+ or CD8+

Not mentioned

N.T

[42]

1/1

a,c CD20+ B cell

Not mentioned

EBV +

[4]

Melanoma

2/2

a CD3+ T cell with CD4+ or CD8+

Not mentioned

N.T

[40]

100% (n = 9)

a CD3+ T cell with CD4+ or CD8+

Not mentioned

N.T

[42]

100% (n = 196)

a T lymphocyte

Not mentioned

N.T

[41]

Sarcoma

1/1

a CD3+ T cell with CD8+ or CD25+

Not mentioned

N.T

[40]

100% (n = 10)

a CD3+ T cell with CD4+ or CD8+

Not mentioned

N.T

[42]

  1. adata from TIL cultivation
  2. bdata form xenograft model
  3. cdata from immunohistology staining of original tumor tissue; N.T.: not detected