A new model of preoperative systemic inflammatory markers predicting overall survival of osteosarcoma: a multicenter retrospective study

Table 1 Clinical characteristics of all patients based on CAR, PLR and NLR

Characteristics	Total	CAR			PLR			NLR
	n=235	LCAR	HCAR	P	LPLR	HPLR	P	LNLR	HNLR	P
Age (years)
≤18	125	77	45	0.074	65	60	0.867	61	64	0.019
>18	110	55	55		56	54		37	73
Sex
Male	156	83	73	0.198	79	77	0.715	61	95	0.256
Female	79	49	30		42	37		37	42
Location
Extremities	208	116	92	0.731	108	100	0.712	90	118	0.176
Non-extremities	27	16	11		13	14		8	19
Tumor size
≤8cm	115	79	36	<0.001	71	44	0.002	54	61	0.110
>8cm	120	53	67		50	70		44	76
Enneking
I	31	26	5	0.002	19	12	0.222	18	13	0.015
II	119	66	53		64	55		54	65
III	85	40	45		38	47		26	59
Subtype
Conventional osteosarcoma	152	85	67	0.772	78	74	0.945	59	93	0.596
Telangiectatic osteosarcoma	15	10	5		6	9		5	10
Small cell osteosarcoma	4	1	3		3	1		3	1
Parosteal osteosarcoma	27	15	12		14	13		12	15
Periosteal osteosarcoma	5	4	1		3	2		3	2
High grade surface osteosarcoma	2	1	1		1	1		1	1
Low-grade central osteosarcoma	30	16	14		16	14		15	15
Pathological fracture
No	211	120	91	0.520	111	100	0.310	86	125	0.384
Yes	24	12	12		10	14		12	12
NACT
No	95	51	44	0.527	47	48	0.611	34	61	0.130
Yes	140	81	59		74	66		64	76
Surgery
No	31	13	18	0.086	10	21	0.021	11	20	0.451
Yes	204	119	85		111	93		87	117
alkaline phosphatase
Normal	99	62	37	0.089	49	50	0.602	47	52	0.126
Elevated	136	70	66		72	64		51	85

CAR C-reactive protein-to-albumin ratio, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, NACT neoadjuvant chemotherapy

ISSN: 1471-2407