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Table 3 Univariate and multivariate analyses of risk factors for overall survival and event-free survival in all enrolled patients

From: Evaluating the prognostic value of CD56 in pediatric acute myeloid leukemia

 

OS of all patients

EFS of all patients

 

Univariate analysis

Risk factors

HR (95% CI)

P

HR (95% CI)

P

≤36 months

4.40 (1.95–9.93)

0.000

3.42 (1.72–6.79)

0.000

High-risk

4.46(1.97–10.09)

0.000

2.50 (1.19–5.28)

0.016

CD56 positivity

1.77 (0.79–3.96)

0.164

1.21(0.61–2.41)

0.581

WBC ≥ 50 × 109/L

1.17(0.50–2.74)

0.716

1.13(0.55–2.34)

0.736

AML1-ETO

0.38(0.13–1.10)

0.074

0.25(0.09–0.72)

0.010

FLT3-ITD

0.04(0.00–32.01)

0.353

1.33(0.41–4.37)

0.636

Complex karyotype

3.34(1.32–8.44)

0.011

2.04(0.84–4.95)

0.177

 

Multivariate analysis

Risk factors

HR (95% CI)

P

HR (95% CI)

P

≤36 months

2.85(1.08–7.50)

0.034

2.97(1.13–7.82)

0.028

High-risk

2.98(1.25–7.10)

0.013

2.74(1.15–6.56)

0.023

AML1-ETO

0.70(0.21–2.37)

0.570

0.56(0.21–2.35)

0.562

Complex karyotype

1.54(0.54–4.42)

0.420

1.25(0.47–3.33)

0.660

  1. Abbreviations: OS overall survival, EFS event-free survival, HR hazard ratio, CI confidence interval, WBC white blood cell count at first diagnosis