Table 3 Analysis of risk factors for shorter RFS

 Age > 70 years

1.06 [0.56–2.02]

0.861

 Sex, male

1.04 [0.54–2.15]

0.904

 BMI > 25 kg·m⁻²

1.30 [0.55–2.72]

0.524

 ASA score ≥ 2

0.87 [0.43–1.96]

0.723

 Charlson comorbidity index ≥ 2

1.27 [0.30–3.55]

0.707

 Preoperative biliary drainage

1.18 [0.61–2.42]

0.638

 Portal vein embolization

1.27 [0.66–2.51]

0.475

 Serum total bilirubin > 1.2 mg/dL

0.73 [0.34–1.47]

0.390

 Serum albumin < 3.8 g/dL

1.06 [0.56–2.06]

0.859

 Serum CA 19–9 > 37 U/mL

1.21 [0.64–2.38]

0.558

 Sarcopenia

0.96 [0.43–1.71]

0.748

 Hepatectomy of more than 4 segments

1.47 [0.75–3.08]

0.268

 Operation time > 500 min

2.17 [1.13–4.28]

0.020

1.53 [0.76–3.13]

0.235

1.67 [0.85–3.37]

0.136

 Blood loss > 1500 mL

1.72 [0.90–3.33]

0.098

 Blood transfusion

1.48 [0.78–2.90]

0.233

 Major complications (Clavien grade ≥ IIIa)

1.53 [0.80–2.90]

0.196

 Surgical site infection

1.44 [0.76–2.76]

0.261

 Bile leakage (ISGLS grade B/C)

0.94 [0.38–2.01]

0.876

 Liver failure (ISGLS grade B/C)

1.52 [0.72–3.00]

0.257

 Length of hospitalization ≥ 20 days

1.60 [0.84–3.16]

0.153

 Tumor size > 25 mm

1.13 [0.59–2.15]

0.714

 T3/4 (UICC 8th)

2.02 [0.99–3.91]

0.053

 Lymph node metastasis

2.68 [1.40–5.21]

0.003

2.01 [1.01–4.04]

0.047

1.62 [0.79–3.34]

0.186

 R1 resection

1.86 [0.98–3.55]

0.059

 Serum CA 19–9 > 37 U/mL

1.75 [0.71–3.76]

0.209

 Sarcopenia

1.40 [0.73–2.66]

0.309

 Decreased SMI

2.91 [1.50–5.90]

0.001

2.14 [1.04–4.57]

0.039

 Serum CA 19–9 > 37 U/mL

6.42 [3.10–13.24]

< 0.001

4.55 [2.10–9.96]

< 0.001

 Sarcopenia

1.81 [0.95–3.50]

0.070

 Decreased SMI

2.27 [1.18–4.52]

0.014

1.25 [0.60–2.66]

0.549