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Fig. 4 | BMC Cancer

Fig. 4

From: Interactions of the chemokines CXCL11 and CXCL12 in human tumor cells

Fig. 4

Combined effects of CXCL12 and CXCL11 on tumor cell invasion. CXCL12 (100 ng/ml)- and/or CXCL11 (100 ng/ml)-induced invasion of tumor cells was analyzed using the Boyden chamber assay in combination with membranes coated with ECM proteins (Matrigel). Cell numbers were determined after 72 h. Number of cells invading the membrane in the absence of chemokines was set to 1. Invasion index was calculated as the ratio of cells invading the membrane in the presence and absence of chemokines. Data show average invasion index (+SD) as determined in 5–7 experiments. CXCL12 and CXCL11 promote invasion of tumor cells with different potencies. CXCL12 in combination with CXCL11 additively promote invasion A549, A772, and MDA-MB-231 cells. In A767 and DLD-1 cells, the simultaneous presence of CXCL11 attenuates the stimulatory influences of CXCL12 on cell invasion. § p < 0.05 treatment vs. control; # p < 0.05 combined treatment vs. CXCL12 and CXCL11 alone; & p < 0.05 combined treatment vs. CXCL12

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