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Fig. 3 | BMC Cancer

Fig. 3

From: Interactions of the chemokines CXCL11 and CXCL12 in human tumor cells

Fig. 3

Signaling pathways mediating the chemotactic responses of tumor cells to CXCL12 and CXCL11. Cultured tumor cells were maintained in the presence or absence of either PD98059 (20 μM), LY294002 (20 μM), or SB203580 (10 μM) for 1 h, and subsequently tested for their migratory responses to CXCL12 (100 ng/ml) and CXCL11 (100 ng/ml) in a modified Boyden chamber as described in Fig. 1. Data represent average migration index (+SD) as determined in 4–10 experiments. Depending on the cell type, chemotactic responses to CXCL12 and CXCL11 differentially involve ERK, PKA, and/or p38. Within a given cell type CXCL12- and CXCL11-induced chemotaxis either depends on identical or different signaling molecules/pathways. #p < 0.05, presence vs. absence of inhibitor

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