Fig. 1
From: Interactions of the chemokines CXCL11 and CXCL12 in human tumor cells
Combined effects of CXCL12 and CXCL11 on tumor cell migration. Chemotactic responses of tumor cells to the indicated concentrations of CXCL12, CXCL11, or a combination of both chemokines were assessed in a modified Boyden chamber for 4 h. The number of cells migrating in the absence of chemokines was set to 1. Migration index was calculated as the ration of cells migrating in the presence and absence of chemokines. Data represent average migration index (+SD) as determined in 4–9 experiments. CXCL12 and CXCL11 induced chemotaxis of the various tumor cells in a dose-dependent manner. At low to medium concentrations, CXCL12 in combination with CXCL11 additively promoted migration of A549 and A767 cells. # p < 0.05, single treatment vs. control. § p < 0.05 double treatment vs. single treatments