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Table 2 Comparing the IC50 values of GemHCl and MFU for Panc-1 and MiaPaCa-2 treated cells in 2-D and 3-D models

From: Synthesis, characterization, and anticancer evaluation of 1,3-bistetrahydrofuran-2yl-5-FU as a potential agent for pancreatic cancer

Cell lines

GemHCl ± SD (μM)

MFU ± SD (μM)

P-Value

MiaPaca-2 (2D)

10.3 ± 1.1

4.5 ± 1.2

< 0.01

Panc-1 (2D)

6.1 ± 1.03

3.0 ± 1.2

0.002

MiaPaca-2 (3D)

14.3 ± 1.1

7.2 ± 1.1

< 0.01

Panc-1 (3D)

16.3 ± 1.1

9.2 ± 1.1

< 0.01

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BMC Cancer

ISSN: 1471-2407

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