Variables | Locoregional recurrence | Distant metastasis | ||||||
---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | |||||
HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
Age (> 60 vs. ≤60) | 1.04 (0.58–1.87) | 0.897 | 0.87 (0.43–1.74) | 0.685 | ||||
Sex (Male vs. Female) | 0.35 (0.11–1.13) | 0.078 | 0.56 (0.16–1.92) | 0.354 | 1.24 (0.37–4.12) | 0.731 | ||
Smoking (Former/current vs. Never) | 1.17 (0.46–2.96) | 0.742 | 1.71 (0.69–4.24) | 0.247 | ||||
Betel nuts (Former/current vs. Never) | 0.71 (0.39–1.29) | 0.254 | 1.04 (0.50–2.17) | 0.909 | ||||
Performance status scale (ECOG ≧1 vs. 0) | 1.82 (1.01–3.30) | 0.048 | 1.54 (0.83–2.86) | 0.175 | 1.17 (0.50–2.73) | 0.715 | ||
Primary tumor location (Oral cavity vs. Others) | 0.69 (0.38–1.25) | 0.220 | 1.26 (0.61–2.58) | 0.537 | ||||
Primary tumor location (Hypolarynx/ larynx vs. others) | 1.69 (0.87–3.28) | 0.119 | 0.86 (0.41–1.78) | 0.675 | ||||
Previous systemic treatment | ||||||||
 Neoadjuvant chemotherapy (Yes vs. No) | 1.36 (0.75–2.48) | 0.310 | 1.31 (0.58–2.96) | 0.509 | ||||
 Primary CCRT (Yes vs. No) | 1.01 (0.56–1.82) | 0.965 | 1.14 (0.53–2.46) | 0.739 | ||||
 Adjuvant CCRT (Yes vs. No) | 0.68 (0.36–1.27) | 0.224 | 0.85 (0.41–1.78) | 0.665 | ||||
Recurrence after RT (<  6 months vs. >  6 months) | 1.28 (0.70–2.33) | 0.426 | 5.32 (2.12–13.40) | < 0.001 | ||||
Treatment | ||||||||
 Salvage surgery (Yes vs. No) | 0.23 (0.08–0.66) | 0.006 | 0.25 (0.10–0.72) | 0.010 | – | |||
 Salvage radiotherapy (Yes vs. No) | 0.71 (0.32–1.60) | 0.408 | – |