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Table 1 Patient and Tumor Characteristics

From: Neoadjuvant docetaxel and capecitabine (TX) versus docetaxel and epirubicin (TE) for locally advanced or early her2-negative breast cancer: an open-label, randomized, multi-center, phase II Trial

 

Total (n = 113) N (%)

TX (n = 54) N (%)

TE (n = 59) N (%)

p

Age

   > 50

58 (51.3)

33 (61.1)

25 (42.4)

0.072

   ≤ 50

55 (48.7)

21 (38.9)

34 (57.6)

 

Histological Type

  No special type

99 (87.6)

47 (87.0)

52 (88.1)

0.853

  Invasive lobular

7 (6.2)

4 (7.4)

3 (5.1)

 

  Mixed

7 (6.2)

3 (5.6)

4 (6.8)

 

Initial cT Stage

  cT0

1 (0.9)

0 (0.0)

1 (1.7)

0.704

  cT1

23 (20.4)

9 (16.6)

14 (23.7)

 

  cT2

70 (61.9)

36 (66.7)

34 (57.6)

 

  cT3

9 (8.0)

5 (9.3)

4 (6.8)

 

  cT4

10 (8.8)

4 (7.4)

6(10.0)

 

Initial cN Stage

  N0

12 (10.6)

7 (13.0)

5 (8.5)

0.730

  N1

46 (40.7)

23 (42.6)

23 (39.0)

 

  N2

44 (38.9)

20 (37.0)

24 (40.7)

 

  N3

11 (9.7)

4 (7.4)

7 (11.9)

 

Hormone Receptor

  Negative

35 (31.0)

15 (27.8)

20 (33.9)

0.618

  Positive

78 (69.0)

39 (72.2)

39 (66.1)

 

  Ki-67

    

   > 20%

72 (63.7)

33 (61.1)

39 (66.1)

0.722

   ≤ 20%

41 (36.3)

21 (38.9)

20 (33.9)

 

Breast Surgery

  Breast conservation

22 (19.5)

11 (20.4)

11 (18.6)

1.000

  Mastectomy

91 (80.5)

43 (79.6)

48 (81.4)

 

  Adjuvant Chemotherapy

95 (84.1)

48 (92.6)

47 (83.1)

0.181

  Original neoadjuvant regimen

64 (64.5)

23 (47.9)

41 (87.2)

 

Non-cross resistant regimen

  Anthracycline + CTX

17 (17.1)

17 (35.4)

0 (0)

 

  Capecitabine alone

6 (6.1)

1 (2.1)

5 (10.6)

 

  Others

8 (8.1)

7 (14.6)

1 (2.1)

 

Adjuvant Radiotherapy

  Yes

109 (96.4)

52 (96.3)

54 (91.5)

0.441

  No

4 (3.6)

2 (3.7)

5 (8.5)

 

Adjuvant Endocrine Therapy

76 (67.3)

37 (68.5)

39 (66.1)

0.784

  TAM

19 (16.8)

9 (16.7)

10 (17.0)

 

  AI

48 (42.5)

25 (46.3)

23 (39.0)

 

  OFS + TAM / AI

9 (8.0)

3 (5.6)

6 (10.1)

 
  1. Abbreviations: CTX Cyclophosphamide, TAM Tamoxifen, AI Aromatase Inhibitor, OFS Ovarian Function Suppression