From: Long term trends of breast cancer incidence according to proliferation status
Observed | Imputeda | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Incidence rate (cases/100000 person-years) | Incidence rate (cases/100000 person-years) | ||||||||||
Age | Women born before 1929 | Women born in 1929 or later | IRD | IRR | (95% CI) | Women born before 1929 | Women born in 1929 or later | IRD | IRR | (95% CI) | |
Totalb | 40–49 | 78.3 | 127.4 | 49.1 | 1.6 | (1.3–2.1) | |||||
50–59 | 110.0 | 214.4 | 104.4 | 1.9 | (1.6–2.3) | ||||||
60–69 | 170.6 | 298.5 | 127.9 | 1.7 | (1.5–2.0) | ||||||
70–79 | 246.5 | 240.6 | −5.9 | 1.0 | (0.8–1.2) | ||||||
Ki-67/500 tumour cells (%) | |||||||||||
< 15 | 40–49 | 16.9 | 34.6 | 17.7 | 2.1 | (1.2–3.4) | 31.9 | 50.2 | 18.3 | 1.6 | (1.0–2.5) |
50–59 | 21.8 | 90.1 | 68.3 | 4.1 | (2.9–5.9) | 49.8 | 124.2 | 74.4 | 2.5 | (1.9–3.3) | |
60–69 | 58.9 | 146.3 | 87.4 | 2.5 | (2.0–3.1) | 92.3 | 186.7 | 94.4 | 2.0 | (1.6–2.5) | |
70–79 | 112.5 | 121.7 | 9.2 | 1.1 | (0.8–1.5) | 151.2 | 147.2 | −4 | 1.0 | (0.7–1.3) | |
≥15 | 40–49 | 15.9 | 51.5 | 35.6 | 3.2 | (1.9–5.4) | 46.1 | 77.1 | 31.0 | 1.7 | (1.2–2.4) |
50–59 | 31.0 | 62.3 | 31.3 | 2.0 | (1.5–2.8) | 60.1 | 90.2 | 30.1 | 1.5 | (1.1–2.0) | |
60–69 | 46.9 | 83.8 | 36.9 | 1.8 | (1.4–2.4) | 78.1 | 111.6 | 33.5 | 1.4 | (1.1–1.8) | |
70–79 | 67.2 | 73.6 | 6.4 | 1.1 | (0.7–1.7) | 94.6 | 93.0 | −1.6 | 1.0 | (0.7–1.4) | |
Mitotic count (mitoses/mm2) | |||||||||||
≤3.6 | 40–49 | 17.8 | 45.4 | 27.6 | 2.5 | (1.5–4.2) | 31.6 | 66.5 | 34.9 | 2.1 | (1.4–3.2) |
50–59 | 20.0 | 101.1 | 81.1 | 5.0 | (3.5–7.3) | 43.2 | 140.6 | 97.4 | 3.3 | (3.4–4.4) | |
60–69 | 60.9 | 163.4 | 102.5 | 2.7 | (2.1–3.4) | 90.5 | 211.9 | 121.4 | 2.3 | (1.9–2.9) | |
70–79 | 110.0 | 138.7 | 28.7 | 1.2 | (0.9–1.6) | 145.3 | 166.6 | 21.3 | 1.1 | (0.9–1.5) | |
> 3.6 | 40–49 | 14.9 | 40.3 | 25.4 | 2.7 | (1.6–4.6) | 46.4 | 60.9 | 14.5 | 1.3 | (0.9–1.9) |
50–59 | 34.6 | 51.4 | 16.8 | 1.5 | (1.1–2.0) | 66.5 | 73.8 | 7.3 | 1.1 | (0.8–1.5) | |
60–69 | 48.8 | 65.9 | 17.1 | 1.3 | (1.0–1.8) | 80.0 | 86.4 | 6.4 | 1.1 | (0.8–1.4) | |
70–79 | 73.8 | 59.4 | −14.4 | 0.8 | (0.5–1.3) | 101.1 | 73.7 | −27.4 | 0.7 | (0.5–1.1) | |
< 7.7 | 40–49 | 26.8 | 66.4 | 39.6 | 2.5 | (1.7–3.7) | 53.6 | 98.6 | 45 | 1.8 | (1.3–2.5) |
50–59 | 38.3 | 132.0 | 93.7 | 3.5 | (2.6–4.5) | 78.8 | 185.4 | 106.6 | 2.4 | (1.9–2.9) | |
60–69 | 90.4 | 198.4 | 108 | 2.2 | (1.8–2.6) | 136.6 | 258.3 | 121.7 | 1.9 | (1.6–2.2) | |
70–79 | 160.0 | 181.2 | 21.2 | 1.1 | (0.9–1.5) | 203.5 | 216.6 | 13.1 | 1.1 | (0.8–1.3) | |
≥7.7 | 40–49 | 5.9 | 19.3 | 13.4 | 3.2 | (1.4–7.5) | 24.3 | 28.8 | 4.05 | 1.2 | (0.7–2.1) |
50–59 | 16.4 | 20.5 | 4.1 | 1.2 | (0.8–2.0) | 30.9 | 28.9 | −2 | 0.9 | (0.6–1.5) | |
60–69 | 19.3 | 30.8 | 11.5 | 1.6 | (1.0–2.5) | 33.8 | 40.0 | 6.2 | 1.2 | (0.8–1.9) | |
70–79 | 29.9 | 17.0 | −12.9 | 0.6 | (0.2–1.3) | 43.0 | 23.7 | −19.3 | 0.6 | (0.3–1.2) |