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Table 2 Uni- and multivariate logistic regression analysis

From: Predictive nomogram based on serum tumor markers and clinicopathological features for stratifying lymph node metastasis in breast cancer

Variable

Univariate analysis

Multi-variate analysis

 

Odds ratio

95% CI

p-value

Odds ratio

95% CI

P value

Age

0.852

0.733–0.999

0.036

0.993

0.975–1.011

0.435

CEA

1.282

1.188–1.384

 < 0.001

1.085

1.001–1.079

0.046

CA125

1.057

1.036–1.078

 < 0.001

1.052

1.027–1.077

 < 0.001

CA153

1.124

1.094–1.154

 < 0.001

1.073

1.042–1.105

 < 0.001

Tumor size

1.313

1.168–1.475

 < 0.001

1.145

1.009–1.299

0.036

Location

 UOQ

Reference

   

 LOQ

0.605

0.327–1.118

0.109

   

 LIQ

0.706

0.398–1.254

0.236

   

 UIQ

0.659

0.395–1.099

0.110

   

 Central

0.398

0.128–1.241

0.112

   

Vascular-invasion

 No

Reference

Reference

 Yes

10.848

6.652–17.690

 < 0.001

7.736

3.903–15.332

 < 0.001

Calcification

 No

Reference

Reference

 Yes

1.900

1.325–2.271

 < 0.001

1.650

1.082–2.514

0.02

Tumor grade

 Well differentiated, grade 1

Reference

   

 Moderately differentiated, grade 2

4.362

1.775–10.718

0.001

5.338

1.514–18.840

0.009

 Poorly differentiated, grade 3

5.657

2.318–13.804

 < 0.001

5.864

1.670–20.594

0.006

Histology subtype

 Invasive ductal carcinoma

Reference

   

 Invasive lobular carcinoma

1.838

0.755–4.477

0.180

   

 Mixed

2.056

0.964–4.379

0.062

   

 Other

0.503

0.215–4.379

0.113

   

ER status

 Negative

0.693

0.447–1.073

0.101

   

 Positive

Reference

   

PR status

 Negative

0.680

0.469–0.986

0.045

   

 Positive

Reference

   

 KI67

1.006

0.998–1.014

0.117

   

Her-2 status

 Negative

0.920

0.626–1.352

0.673

   

 Positive

Reference

   

Biological subtype

 Luminal A

1.147

0.532–2.474

0.726

   

 Luminal B

1.932

1.046–3.567

0.035

   

 Her-2 positive

1.554

0.706–3.421

0.273

   

 TNBC

Reference

   
  1. Abbreviation: Her-2 Human epidermal growth factor receptor-2, TNBC Triple negative breast cancer, LIQ Lower-inner quadrant, LOQ Lower-outer quadrant, UIQ Upper-inner quadrant, UOQ Upper-outer quadrant