Fig. 6From: MYEOV overexpression induced by demethylation of its promoter contributes to pancreatic cancer progression via activation of the folate cycle/c-Myc/mTORC1 pathwaySchematic of the roles of MYEOV in pancreatic cancer. A, In normal cells, MYEOV expression is low, and MXD4 and CASTOR2 appropriately suppress c-Myc and mTORC1. B, In tumors, MYEOV expression is upregulated and promotes the downregulation of MXD4 and CASTOR2, which induces the activation of c-Myc and mTORC1 and contributes to tumor progressionBack to article page