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Fig. 10 | BMC Cancer

Fig. 10

From: Tumor cell-derived conditioned medium induced pro-tumoral phenotypes in macrophages through calcium-nuclear factor κB interaction

Fig. 10

Summarization of the related mechanisms. LL-2-CM inhibited expression of calcium channels and decreased cytosolic calcium concentration, which inhibited activation of NF-κB. On the contrary, LPS was able to elevate cytosolic calcium concentration, elicit canonical NF-κB, and stimulate M1-like polarization of BMDMs. Created with Biorender.com

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