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Table 3 Time-Updated Metabolic Labs and Breast Cancer Survival, Stratified by Age, Diabetes Status, Estrogen Receptor Status, and Body Mass Index

From: Metabolic abnormalities and survival among patients with non-metastatic breast cancer

 

Low Glucose1,2

(< 60 mg/dL)

High Glucose1,2 (> 99 mg/dL)

Low HDL1,2

(≤ 45 mg/dL)

High LDL1,2

(≥ 129 mg/dL)

High Triglycerides1,2 (≥ 199 mg/dL)

HR3

95% CI3

p-value

HR3

95% CI3

p-value

HR3

95% CI3

p-value

HR3

95% CI3

p-value

HR3

95% CI3

p-value

Pre-menopause (< 55 yrs) (n = 3,540; events = 245)

3.47

0.44, 27.1

0.24

1.24

0.89, 1.73

0.20

1.70

1.26, 2.29

< 0.001

0.85

0.64, 1.14

0.29

0.79

0.51, 1.22

0.29

Post-menopause (> = 55 yrs) (n = 9,894; events = 835)

5.97

2.19, 16.2

< 0.001

1.19

1.01, 1.39

0.035

1.78

1.50, 2.10

< 0.001

0.90

0.76, 1.06

0.19

1.03

0.84, 1.27

0.78

ER negative (n = 2,214; events = 323)

3.35

0.45, 24.6

0.24

1.14

0.87, 1.49

0.34

1.88

1.43, 2.47

< 0.001

1.15

0.90, 1.47

0.25

0.96

0.67, 1.38

0.83

ER positive (n = 11,164; events = 753)

6.64

2.44, 18.1

< 0.001

1.21

1.02, 1.43

0.027

1.74

1.47, 2.07

< 0.001

0.83

0.70, 1.00

0.044

0.97

0.78, 1.21

0.77

No Diabetes (n = 9,711; events = 764)

–-

–-

–-

1.41

1.21, 1.65

< 0.001

2.09

1.75, 2.50

< 0.001

0.91

0.78, 1.07

0.25

0.91

0.71, 1.17

0.46

Diabetes (n = 3,723; events = 316)

6.21

2.44, 15.8

< 0.001

0.77

0.58, 1.03

0.079

1.36

1.07, 1.73

0.012

0.86

0.63, 1.17

0.34

1.15

0.86, 1.53

0.34

Normal (18.5—< 25 kg/m2) (n = 3,592; events = 268)

2.44

0.32, 18.7

0.39

1.03

0.77, 1.38

0.83

1.82

1.30, 2.55

< 0.001

0.71

0.54, 0.95

0.022

1.29

0.84, 1.97

0.25

Overweight (25—< 30 kg/m2) (n = 4,247; events = 309)

16.0

4.93, 51.6

< 0.001

0.84

0.65, 1.10

0.21

1.30

0.98, 1.73

0.070

0.95

0.73, 1.23

0.69

0.69

0.47, 1.00

0.049

Class 1 Obesity (30—< 35 kg/m2) (n = 2,689; events = 233)

1.41

0.19, 10.3

0.73

1.07

0.79, 1.44

0.68

1.41

1.06, 1.88

0.020

1.03

0.76, 1.40

0.84

1.25

0.89, 1.75

0.21

Class 2/3 Obesity (≥ 35 kg/m2) (n = 2,193; events = 197)

–-

–-

–-

1.08

0.77, 1.51

0.67

1.66

1.24, 2.23

< 0.001

0.72

0.50, 1.05

0.084

0.91

0.62, 1.35

0.65

  1. 1All laboratory reference levels are normal
  2. 2Models adjusted for age at diagnosis, race/ethnicity, stage at diagnosis, ER and HER2 status, receipt of chemotherapy, and time-updated metabolic labs, body mass index, diabetes, tamoxifen and aromatase inhibitors, and dyslipidemia medications
  3. 3HR Hazard ratio, CI Confidence interval
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BMC Cancer

ISSN: 1471-2407

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