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Fig. 4 | BMC Cancer

Fig. 4

From: Anti-cancer effect of afatinib, dual inhibitor of HER2 and EGFR, on novel mutation HER2 E401G in models of patient-derived cancer

Fig. 4

Evaluation of drug efficacy using xenografts derived from patient’s cancer bearing amplified HER2 E401G. A Tumor size in each drug group and vehicle group in patient-derived xenografts (PDX). Error bars represent SD. *P < 0.05 and **P < 0.01. T + P, trastuzumab and pertuzumab; Lp 100, Lapatinib 100 mg/kg; Lp 150, Lapatinib 150 mg/kg. B Appearance of tumors at the time of sacrificed (day22). C HER2 copy number at the end of treatment. DNA was extracted from the tumor excised on day 22 and HER2 copy number was analyzed by droplet digital PCR

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