Table 3 GO pathway analysis of upregulated DEGs related with CRA
ONTOLOGY | ID | Description | p value | p.adjust | geneID | Count |
|---|---|---|---|---|---|---|
BP | GO:0,061,844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 1.8644E-07 | 0.000194 | DEFA5/DEFA6/REG3A/KLK7/REG1A/REG1B/CXCL11 | 7 |
BP | GO:0,002,283 | neutrophil activation involved in immune response | 2.1103E-05 | 0.00529344 | SERPINA3/ANXA3/CD44/CHI3L1/CD55/LCN2/SERPINA1/S100A8/S100P/TCN1/OLFM4/QPCT | 12 |
BP | GO:0,042,119 | neutrophil activation | 2.5754E-05 | 0.00529344 | SERPINA3/ANXA3/CD44/CHI3L1/CD55/LCN2/SERPINA1/S100A8/S100P/TCN1/OLFM4/QPCT | 12 |
BP | GO:0,043,062 | extracellular structure organization | 2.7981E-05 | 0.00529344 | CD44/COL9A3/HYAL1/LPL/MMP7/MMP12/TNFRSF11B/SERPINB5/KLK7/TGFBI/TIMP1 | 11 |
BP | GO:0,006,959 | humoral immune response | 3.5213E-05 | 0.00563673 | CD55/DEFA5/DEFA6/LCN2/REG3A/KLK7/REG1A/REG1B/S100A8/CXCL11 | 10 |
BP | GO:0,050,673 | epithelial cell proliferation | 0.00018119 | 0.01561372 | BMP4/CDH3/ECM1/HYAL1/MMP12/REG3A/SERPINB5/REG1A/LGR5/SDR16C5 | 10 |
CC | GO:0,034,774 | secretory granule lumen | 2.0346E-08 | 2.1909E-06 | SERPINA3/CHI3L1/DEFA5/ECM1/LCN2/PCSK1/SERPINA1/S100A8/S100P/TCN1/TIMP1/OLFM4/QPCT | 13 |
CC | GO:0,060,205 | cytoplasmic vesicle lumen | 3.7348E-08 | 2.1909E-06 | SERPINA3/CHI3L1/DEFA5/ECM1/LCN2/PCSK1/SERPINA1/S100A8/S100P/TCN1/TIMP1/OLFM4/QPCT | 13 |
CC | GO:0,031,983 | vesicle lumen | 3.8664E-08 | 2.1909E-06 | SERPINA3/CHI3L1/DEFA5/ECM1/LCN2/PCSK1/SERPINA1/S100A8/S100P/TCN1/TIMP1/OLFM4/QPCT | 13 |
CC | GO:0,035,580 | specific granule lumen | 2.1678E-05 | 0.00092129 | CHI3L1/LCN2/TCN1/OLFM4/QPCT | 5 |
CC | GO:0,042,581 | specific granule | 0.00023912 | 0.00813023 | ANXA3/CHI3L1/LCN2/TCN1/OLFM4/QPCT | 6 |
CC | GO:0,062,023 | collagen-containing extracellular matrix | 0.00036907 | 0.01045705 | SERPINA3/COL9A3/ECM1/SERPINA1/SERPINE2/S100A8/TGFBI/TIMP1/SBSPON | 9 |
MF | GO:0,005,539 | glycosaminoglycan binding | 8.0044E-09 | 2.1052E-06 | BMP4/CD44/LPL/MMP7/REG3A/SERPINE2/REG1A/REG1B/CXCL11/FGFRL1/CEMIP/REG4 | 12 |
MF | GO:0,008,201 | heparin binding | 5.515E-05 | 0.00705108 | BMP4/LPL/MMP7/SERPINE2/CXCL11/FGFRL1/REG4 | 7 |
MF | GO:0,070,492 | oligosaccharide binding | 8.0431E-05 | 0.00705108 | REG3A/REG1A/REG1B | 3 |
MF | GO:0,005,201 | extracellular matrix structural constituent | 0.00253168 | 0.0443887 | CHI3L1/COL9A3/ECM1/TGFBI/SBSPON | 5 |
MF | GO:0,008,083 | growth factor activity | 0.00253168 | 0.0443887 | BMP4/REG1A/TDGF1/TDGF1P3/TIMP1 | 5 |
MF | GO:0,001,227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | 0.0027753 | 0.04561902 | ASCL2/DACH1/MSX2/TBX3/NFE2L3/FOXQ1 | 6 |