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Fig. 7 | BMC Cancer

Fig. 7

From: Intense endoplasmic reticulum stress (ERS) / IRE1α enhanced Oxaliplatin efficacy by decreased ABCC10 in colorectal cancer cells

Fig. 7

Scheme of intense ERS effect on ABCC10-medicated Oxaliplatin efflux. Oxaliplatin is the substrate of ABCC10, which accelerates efflux of Oxaliplatin so as to reduce its intracellular accumulation. Intense ERS/UPR down-regulates ABCC10 via IRE1α pathway, which increases Oxaliplatin accumulation in CRC cells and consequently sensitizes CRC cells. In addition, intense ERS/UPR up-regulates pro-apoptotic factor CHOP and promotes CRC cell apoptosis. Bolt of lightning denotes ERS stimulus

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BMC Cancer

ISSN: 1471-2407

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