Fig. 1

ABCC10 is positively correlated with IC50 of Oxaliplatin and contributes to CRC malignancy. a ABCC10 protein is undifferentiated between CRC tissues and adjacent normal mucosal tissues. n = 30. Uncropped blots are provided in Supplementary information Fig. S9. b There is no obvious difference in ABCC10 mRNA level between CRC tissues and normal mucosa by GEPIA2 data analysis. c CRC patients with higher ABCC10 are prone to metastasis. M0: no metastasis, M: metastasis. * P < 0.05. d CRC patients with higher ABCC10 are prone to recurrence post initial therapy. * P < 0.05. e ABCC10 level in CRC patients with tumor is significantly higher when compared with those without tumor. * P < 0.05. (f) CRC patients with lower ABCC10 survive those with higher ABCC10 by GEPIA2 data analysis. g The basic ABCC10 protein expression in 5 CRC cell lines and NCM460 normal colonic epithelial cell line. n = 3. *** P < 0.001. Uncropped blots are provided in Supplementary information Fig. S10. h The basic ABCC10 mRNA expression in 5 CRC cells lines and NCM460 normal colonic epithelial cell line. n = 3. * P < 0.05, *** P < 0.001. i The CRC cells are treated with a gradient of Oxaliplatin (10, 20, 40, 80 and 160 ng/mL) for 24 h. The IC50 of Oxaliplatin in 5 CRC cell lines is calculated according to the cellular viability. n = 6. j Pearson correlation indicates a positive correlation between the ABCC10 protein level and IC50 of Oxaliplatin in 5 CRC cell lines. n = 6