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Table 4 Univariate Cox Regression analyses for association of biomarkers with clinical outcome

From: Markers associated with genomic instability, immunogenicity and immune therapy responsiveness in Metaplastic carcinoma of the breast: Expression of γH2AX, pRPA2, P53, PD-L1 and tumor infiltrating lymphocytes in 76 cases

 

Disease free Survival

Overall Survival

Biomarkers

HR (95% CI)

P Value

HR (95% CI)

P Value

P53 ≥ 10%/ < 10%

1.30 (0.54 – 3.12)

0.554

1.57 (0.63 – 3.92)

0.339

tcPD-L1, %

1.01 (1.00 – 1.02)

0.032

1.01 (1.00 – 1.02)

0.035

icPD-L1, %

1.00 (0.98 – 1.02)

0.953

1.00 (0.99 – 1.02)

0.787

γH2AX, %

0.99 (0.97 – 1.01)

0.159

0.99 (0.98 – 1.01)

0.268

RPA2%

0.99 (0.98 – 1.01)

0.457

0.99 (0.97 – 1.01)

0.290

iTIL, %

1.03 (0.92 – 1.15)

0.627

1.03 (0.93 – 1.15)

0.534

sTIL, %

0.99 (0.96 – 1.03)

0.662

0.99 (0.96 – 1.02)

0.454

  1. HR hazard ratio, CI confidence interval, tcPD-L1 tumor cell PD-L1, icPD-L1 immune cell PD-L1, iTIL intratumoral tumor-infiltrating lymphocytes, sTIL stromal tumor-infiltrating lymphocytes
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BMC Cancer

ISSN: 1471-2407

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