Table 3 Expression of biomarkers across different histological subtypes
Subtype (n) | P53 ≥ 10% n (%) n = 74 | tcPD-L1 median, (range) n = 73 | icPD-L1 median, (range) n = 73 | tcPD-L1 ≥ 1% n (%) n = 73 | icPD-L1 ≥ 1% n (%) n = 73 | γH2AX median, (range) n = 75 | RPA2 median, (range) n = 74 | iTIL median, (range) n = 76 | sTIL median, (range) n = 76 |
|---|---|---|---|---|---|---|---|---|---|
Low grade adenosquamous (1) | 0 (0) | 0 (0–0) | 30 (30–30) | 0 (0) | 1 (100) | 0 (0–0) | 5 (5–5) | ||
Squamous (19) | 15 (83) | 13 (0 – 100) | 20 (0 – 60) | 11 (61) | 13 (72) | 43 (8 – 78) | 40 (7 – 73) | 1 (0 – 10) | 7 (0 – 60) |
Spindle (17) | 12 (71) | 30 (0 – 100) | 5 (0 – 80) | 13 (77) | 12 (71) | 43 (6 – 85) | 40 (3 – 75) | 3 (0 – 20) | 3 (0 – 40) |
Carcinoma with mesenchymal differentiation (13) | 8 (62) | 0 (0 – 5) | 0 (0 – 40) | 3 (25) | 4 (33) | 49 (15 – 83) | 58 (12 – 81) | 0 (0 – 2) | 0 (0 – 40) |
Mixed metaplastic (9) | 6 (67) | 7 (0 – 100) | 20 (0 – 60) | 7 (78) | 7 (78) | 49 (12 – 85) | 25 (3 – 75) | 1 (0 – 5) | 5 (1 – 20) |
Mixed type (17) | 9 (56) | 2 (0 – 90) | 1 (0 – 70) | 9 (56) | 8 (50) | 38 (5 – 79) | 50 (4 – 80) | 0 (0 – 2) | 5 (0 – 50) |
P value | 0.375b | 0.010a | 0.368a | 0.893a | 0.271a | < 0.0005a | 0.096a |