Table 3 Adverse events
Toxicity / Grade | Grade 1, N (%) | Grade 2, N (%) | Grade 3, N (%) | Grade 4, N (%) |
|---|---|---|---|---|
Clinical | ||||
Abdominal pain | 11 (52) | 5 (24) | – | – |
Anorexia | 6 (29) | 2 (10) | – | – |
Back pain | 5 (24) | – | – | – |
Constipation | 5 (24) | – | – | – |
Diarrhea | 9 (43) | 2 (10) | 1 (5) | – |
Dysgeusia | 4 (19) | 1 (5) | – | – |
Emesis | 7 (33) | 1 (5) | – | – |
Fatigue | 7 (33) | 4 (19) | – | – |
Fever | 4 (19) | – | – | – |
Headache | 3 (14) | – | – | – |
Insomnia | 4 (19) | – | – | – |
Nausea | 10 (48) | 3 (14) | – | – |
Night sweats | 3 (14) | – | – | – |
Laboratory | ||||
ALT elevation | 8 (38) | 1 (5) | – | – |
AST elevation | 10 (48) | 4 (19) | – | – |
Bilirubin elevation | 3 (14) | 3 (14) | 2 (10) | – |
Hypoalbuminemia | 3 (14) | 2 (10) | 2 (10) | – |
Anemia | 3 (14) | 3 (14) | 5 (24) | – |
Leukopenia | 2 (10) | 4 (19) | 4 (19) | 1 (5) |
Neutropenia | 2 (10) | 3 (14) | 7 (33) | 3 (14) |
Neutropenic fever | – | – | 1 (5) | – |
Thrombocytopenia | 8 (38) | 4 (19) | 1 (5) | – |