Skip to main content
Fig. 4 | BMC Cancer

Fig. 4

From: Identification of CEACAM5 as a stemness-related inhibitory immune checkpoint in pancreatic cancer

Fig. 4

Function and regulation of the stemness-related inhibitory immune checkpoint in pancreatic cancer. A-D GSEA of pancreatic cancers with high vs. low expression of CEACAM5. A Interferon-γ response. B Prostanoid metabolic process. C Unsaturated fatty acid metabolic process. D Long-chain fatty acid metabolic process. E Violin plots for CEACAM5 expression in multiple immune subtypes of pancreatic cancer (P = 0.0125). C1, wound healing; C2, IFN-γ dominant; C3, inflammatory; C4, lymphocyte depleted; C5, TGF-β dominant. F Spearman’s correlation between CEACAM5 expression and prostanoid metabolic process in pancreatic cancer. G Spearman’s correlation between CEACAM5 expression and unsaturated fatty acid metabolic process in pancreatic cancer. H Spearman’s correlation between CEACAM5 expression and long-chain fatty acid metabolic process in pancreatic cancer. I Spearman’s correlation between CEACAM5 expression and infiltration of neutrophils in pancreatic cancer. J Spearman’s correlation between CEACAM5 expression and infiltration of M1 macrophages in pancreatic cancer. K Kaplan–Meier curves for overall survival split by level of CEACAM5 expression and infiltration level of neutrophils in pancreatic cancer. L Kaplan–Meier curves for overall survival split by level of CEACAM5 expression and infiltration level of M1 macrophages in pancreatic cancer

Back to article page