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Table 6 Univariate and Multivariate logistic regression of the factors associated with clinically significant DDIs among cancer patients, Uganda

From: Frequency, severity, and factors associated with clinically significant drug-drug interactions among patients with cancer attending Mbarara Regional Referral Hospital Cancer Unit, Uganda

Independent variables

Univariate logistic regression

Multivariable logistic regression

Variables

Categories

COR (95% C.I)

P value

aOR (95% C.I)

P value

Gendera

Female

1.61 (1.00–2.57)

.049

2.61 (1.37- 4.96)

.003

Male

1

 

1

 

Age in yearsa

 < 18

1

 

1

 

18–59

2.36 (1.22–4.55)

0.011

0.01 (0.0–1.1)

0.999

 >  = 60

1.54 (.79–2.98)

0.202

0.02 (0–1.3)

0.998

Warda

Adult

2.02 (1.09–3.72)

.025

2.01 (.71–5.70)

.188

Pediatrics

1

 

1

 

Admission statusa

In Patient

1.75 (.95–3.21)

.071

-

-

Out Patient

1

 

-

-

Place of residence

Urban

.88 (.49–1.59)

.676

-

-

Rural

1

 

-

-

Marital statusa

Married

.36 (.13-.99)

.048

.51 (.14–1.84)

.300

Single

.32 (.09–1.13)

.076

.24 (.05–1.18)

.078

Separated/Divorced/ Widowed

1

 

1

 

Employment status

Unemployed

1.10 (.54–2.23)

.797

-

-

Employed

1

 

-

-

Level of educationa

None

.704 (.35–1.42)

.325

.46 (.19–1.16)

.101

Primary

.620 (.33–1.17)

.142

.48 (.20–1.15)

.100

Secondary/Tertiary

1

 

1

 

Previous admissiona

No

.72 (.45–1.15)

.172

.84 (.41–1.72)

.638

Yes

1

 

1

 

Previous or concurrent radiation/surgery

No

1.02 (.61–1.70)

.941

-

-

Yes

1

 

-

-

Any Comorbiditya

No

1

 

1

 

Yes

2.37 (1.46–3.83)

P < .001

1.47 (.74–2.94)

.272

Total drugsa

 < 6

1

 

1

 

 ≥ 6

16.49 (9.25–29.38)

P < .001

9.14 (4.80–17.43)

P < 0.001

Duration since diagnosisa

 < 2

1.70 (1.02–2.82)

.040

1.07 (.50–2.28)

.855

 >  = 2

1

 

1

 

Presence of metastasis

Yes

.96 (.45–2.02)

.907

-

-

No

1

 

-

-

  1. COR Crude Odds Ratio, aOR Adjusted Odds Ratio
  2. Bold: Statistically significant (p value < 0.05)
  3. aEligible for Multivariable logistic regression (P value < 0.25)